Lupus anticoagulant and venous leg ulceration

The British Journal of Dermatology
A M FinkAndreas Steiner

Abstract

Most leg ulcers occur in patients with venous insufficiency. However, not all patients with venous insufficiency develop leg ulcers. Recent studies have found that factors causing clotting abnormalities, e.g. anticardiolipin antibody (ACA), are associated with leg ulcers. Although lupus anticoagulant, like ACA, belongs to the group of antiphospholipid antibodies, its presence in patients with venous leg ulceration has not been previously reported. To determine the presence of lupus anticoagulant in patients with venous leg ulceration. We investigated the presence of lupus anticoagulant in 27 patients with venous leg ulcers and compared these data with controls. Lupus anticoagulant was evaluated in all subjects by the Russell's viper venom test. Of 27 patients with venous leg ulceration, 16 (59%) were shown to have lupus anticoagulant, while only one of 32 controls (3%) was found to have lupus anticoagulant. Thus, lupus anticoagulant was significantly more frequent in patients with venous leg ulcers than in controls (P < 0.001). We suggest that lupus anticoagulant could be a hitherto unknown factor contributing to the development of venous leg ulcers.

References

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Citations

Jun 2, 2005·Journal of the American Academy of Dermatology·Mark B GibbsMatthew J Zirwas
Dec 31, 2003·Journal of the American Academy of Dermatology·Jan R MekkesJan D Bos
Jun 13, 2013·Journal of Tissue Viability·Ganary Dabiri, Vincent Falanga
Jul 1, 2006·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Bo JørgensenFinn Gottrup
Oct 27, 2015·Indian Dermatology Online Journal·Vijaya Veeranna SajjanAshok Maharudrayya Pandit
Mar 25, 2009·Journal of Vascular Surgery·Katy A L DarvallAndrew W Bradbury
Nov 30, 2018·British Journal of Haematology·Matthew K H TanAlun H Davies
Mar 26, 2003·The British Journal of Dermatology·J R MekkesJ D Bos

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