Abstract
The prevalence of lupus anticoagulant, using the dilute Russell's viper venom time (DRVT), was determined in 22 patients with mild to severe haemophilia A to see if there was any association with the presence of viral disease. Twelve haemophiliacs (58%) were lupus anticoagulant positive, with a mean patient:control ratio of 1.24 (range 1.15-1.52, normal range 0.84-1.06 which partially corrected with lysed, washed platelets). Nine of these patients were IgG or IgM, or both, anticardiolipin antibody positive and nine were human immunodeficiency virus (HIV) antibody positive, but associations between lupus anticoagulant, anticardiolipin antibodies, and HIV antibody positivity were not significant. Mixing studies of normal plasma and immune depleted factor VIII deficient plasma showed that the DRVT ratio increased when the factor VIII concentration fell below 0.15 IU/ml. There was no significant association between plasma factor VIII concentration and positive DRVT results in haemophiliacs. The addition of porcine factor VIII concentrate produced no correction in eight of the 12 with DRVTs indicative of lupus anticoagulant, suggesting that these were prolonged by antiphospholipid activity. It is concluded that the presence of lupus...Continue Reading
References
Sep 12, 1987·Lancet·R MisraR N Maini
Feb 1, 1986·Annals of Internal Medicine·A J CohenC M Kessler
May 8, 1986·The New England Journal of Medicine·J E GoldR Zalusky
Feb 1, 1988·British Journal of Haematology·W BrienG Denome
Apr 1, 1987·British Journal of Haematology·R T CanosoJ E Groopman
Oct 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·D R JarvieE H Dyson
Nov 1, 1987·British Journal of Haematology·I J MackieS J Machin
Aug 1, 1985·Molecular Immunology·C J Lobb
Nov 26, 1983·Lancet·E N HarrisG R Hughes
Jan 1, 1983·Scandinavian Journal of Rheumatology·A K TrullA Ebringer
Jan 1, 1982·Haemostasis·R F Zwaal, H C Hemker
Citations
Dec 31, 1997·AIDS·P S MassabkiL E Andrade
Dec 1, 1993·British Journal of Haematology·J MatsudaM Tsukamoto
May 1, 1994·Annals of the Rheumatic Diseases·J MatsudaN Saitoh
Jan 1, 1991·Journal of Clinical Pathology·F CassaniF B Bianchi
Dec 1, 1994·British Journal of Haematology·A al-SaeedM Greaves
Jun 12, 1999·Journal of Hepatology·F J Muñoz-RodríguezM Ingelmo
Oct 1, 1992·American Journal of Obstetrics and Gynecology·R R ViscarelloJ C Hobbins
Apr 16, 1998·European Journal of Clinical Investigation·J ConstansC Conri
Jul 6, 2014·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Paul R J AmesLuigi Iannaccone
Jul 14, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·A G RampersadA Shapiro
May 1, 1994·Annals of the Rheumatic Diseases·M Gross
Aug 16, 2005·Clinical Chemistry·Armando TripodiPier Mannuccio Mannucci
Aug 1, 1991·Cancer·G D HigginsC J Burrell
Nov 1, 1995·American Journal of Hematology·M Gotoh, J Matsuda
Jul 1, 1997·Medicine, Science, and the Law·B M CravenM Khan
Aug 1, 1990·Clinical and Experimental Immunology·C MacleanD C Kilpatrick
Jun 1, 1993·American Journal of Hematology·J MatsudaM Hashimoto
Jan 1, 1994·Clinical Microbiology Reviews·C M Tsoukas, N F Bernard