PMID: 2500459Jun 1, 1989Paper

Lupus anticoagulant, anticardiolipin antibodies, and human immunodeficiency virus in haemophilia

Journal of Clinical Pathology
H CohenS J Machin

Abstract

The prevalence of lupus anticoagulant, using the dilute Russell's viper venom time (DRVT), was determined in 22 patients with mild to severe haemophilia A to see if there was any association with the presence of viral disease. Twelve haemophiliacs (58%) were lupus anticoagulant positive, with a mean patient:control ratio of 1.24 (range 1.15-1.52, normal range 0.84-1.06 which partially corrected with lysed, washed platelets). Nine of these patients were IgG or IgM, or both, anticardiolipin antibody positive and nine were human immunodeficiency virus (HIV) antibody positive, but associations between lupus anticoagulant, anticardiolipin antibodies, and HIV antibody positivity were not significant. Mixing studies of normal plasma and immune depleted factor VIII deficient plasma showed that the DRVT ratio increased when the factor VIII concentration fell below 0.15 IU/ml. There was no significant association between plasma factor VIII concentration and positive DRVT results in haemophiliacs. The addition of porcine factor VIII concentrate produced no correction in eight of the 12 with DRVTs indicative of lupus anticoagulant, suggesting that these were prolonged by antiphospholipid activity. It is concluded that the presence of lupus...Continue Reading

References

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Citations

Dec 31, 1997·AIDS·P S MassabkiL E Andrade
Jan 1, 1991·Journal of Clinical Pathology·F CassaniF B Bianchi
Jun 12, 1999·Journal of Hepatology·F J Muñoz-RodríguezM Ingelmo
Jul 6, 2014·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Paul R J AmesLuigi Iannaccone
Jul 14, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·A G RampersadA Shapiro
Jul 1, 1997·Medicine, Science, and the Law·B M CravenM Khan
Aug 1, 1990·Clinical and Experimental Immunology·C MacleanD C Kilpatrick
Jan 1, 1994·Clinical Microbiology Reviews·C M Tsoukas, N F Bernard

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