Lupus anticoagulant associated with specific inhibition of factor VII in a patient with AIDS

American Journal of Clinical Pathology
O K NdimbieS M Saeed

Abstract

A 37-year-old intravenous drug abuser with acquired immune deficiency syndrome showed elevated activated partial thromboplastin time (APTT) and prothrombin time, normal thrombin time and fibrinogen, and borderline low platelet counts. The patient subsequently had a fracture of the left zygomatic arch, which did not produce uncontrollable bleeding. The coagulogram repeated at this admission showed persistent elevation of APTT. Further coagulation workup showed the presence of a lupus anticoagulant with mild specific inhibition of Factor VII. Platelet aggregation and Factor II levels were normal.

Citations

Mar 29, 2002·Bone Marrow Transplantation·A A ToorN S Key
Feb 18, 2003·British Journal of Haematology·Carlos J BidotYeon S Ahn
Nov 15, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Sean LimC Jason Mainwaring
Sep 25, 2015·Acta Clinica Belgica·Sylvie M N Mulliez, Katrien M J Devreese
Feb 1, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·C AguilarP Hernández
Jan 16, 2016·Therapeutic Advances in Gastroenterology·Muhammad Wasif SaifRobert B Diasio
Aug 16, 2002·British Journal of Haematology·David J Perry
May 29, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Charles G MullighanJohn V Lloyd
Jun 11, 2020·Journal of Pediatric Hematology/oncology·Abed Abu-QuiderJoseph Kapelushnik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
Ginell R PostMayumi Nakagawa
The British Journal of Psychiatry : the Journal of Mental Science
C S Thomas, E Szabadi
Ugeskrift for laeger
L J Friis-HansenE Scheibel
© 2022 Meta ULC. All rights reserved