Lupus anticoagulant in immune thrombocytopenic purpura

Indian Journal of Pediatrics
Sumitra DashSambit Mohanty

Abstract

Antibodies against phospholipid antigens (APA) have been demonstrated in adult idiopathic(immune) thrombocytopenic purpura (ITP), but their clinical and pathogenetic significance has remained elusive. Also there are no such studies available in pediatric ITP cases. In this study, the prevalence and clinical significance of APAs were investigated in pediatric patients with ITP. Forty newly diagnosed ITP patients (age 2-13 years) were prospectively studied. They were evaluated for the presence of lupus anticoagulant (LA). Eleven patients (27.5%) were LA positive at the time of diagnosis. No statistically significant differences were found between the LA-positive and LA-negative groups regarding gender, initial platelet counts, or response to methyl prednisolone therapy. After 6 months of follow up, 5 of the 11 LA-positive cases were still positive for LA. The frequency of LA positivity found in this pediatric age group was similar to that reported in adult patients. In view of the fact that in adult patients with ITP, the persistent presence of APAs is an important risk factor for the development of antiphospholipid syndrome, the same may also hold true for pediatric ITP patients, and thus 'demands long term follow up for these p...Continue Reading

Citations

Oct 16, 2007·Current Opinion in Hematology·Howard A Liebman, Roberto Stasi
Apr 25, 2008·Pediatric Hematology and Oncology·Bacel Nseir, Jyoti Panicker
Mar 31, 2009·Seminars in Hematology·Douglas B CinesRoberto Stasi
Mar 31, 2009·Seminars in Hematology·James B Bussel
Jan 26, 2008·Seminars in Hematology·Howard Liebman
Jun 29, 2007·Journal of Korean Medical Science·Chang Moo KangYoo Hong Min
Apr 14, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Aniruddha DayamaRenu Saxena
Jan 9, 2008·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Eman A El-BostanyEsmat A El-Ghafar

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.