Lupus anticoagulants, anticardiolipin antibodies, and cerebral ischemia

Stroke; a Journal of Cerebral Circulation
M J Kushner, N Simonian

Abstract

We studied 23 patients suffering cerebral ischemia who also had laboratory evidence of either a lupus anticoagulant (LA) or an abnormal anticardiolipin antibody (ACA). Four patients had lupus or a lupus-like illness, three had drug-induced lupus, and 16 had no overt evidence of collagen-vascular disease. Cerebral ischemic events were multiple in 71% of the patients; two patients presented with multi-infarct dementia. Recognized cerebrovascular disease risk factors were present in 57% of the patients. The partial thromboplastin time was prolonged in only 35% of the patients. An LA was identified in 15 of 21 patients tested, and an elevated ACA titer was identified in 10 of 12 patients tested. Simultaneous assays for LA and ACA were discordant in eight of 10 patients tested. LA- and ACA-associated brain ischemia is often recurrent, but other risk factors for cerebrovascular disease are often present. The laboratory findings in such patients may display considerable heterogeneity.

References

Nov 1, 1976·Arthritis and Rheumatism·M BoxerA Carvalho
Mar 1, 1975·Acta Medica Scandinavica·I M NilssonD Berezin
Feb 1, 1986·Annals of Internal Medicine·A J CohenC M Kessler
Jul 1, 1986·American Journal of Hematology·L R Espinoza, R C Hartmann
Aug 1, 1986·Archives of Neurology·N F Tabachnik-Schor, S A Lipton
Sep 1, 1986·Neurology·M Fisher, W McGehee
Jan 1, 1986·Scandinavian Journal of Rheumatology·R H DerksenL Kater
Jan 22, 1988·JAMA : the Journal of the American Medical Association·D A TriplettC A Orr
Mar 1, 1987·The American Journal of Emergency Medicine·R K KanterJ J Zimmerman
Jul 1, 1987·Arthritis and Rheumatism·J G FortJ B Smith
Jul 1, 1985·American Journal of Hematology·D A GastineauE J Bowie
Mar 1, 1984·Archives of Internal Medicine·M Elias, A Eldor
Oct 15, 1983·British Medical Journal·G R Hughes
May 1, 1983·Stroke; a Journal of Cerebral Circulation·G LandiL Candelise
Apr 1, 1984·British Journal of Obstetrics and Gynaecology·W F LubbeG C Liggins
May 1, 1984·Archives of Neurology·R E KelleyA G Kovacs
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Feb 1, 1980·Annals of Internal Medicine·J R MuehS I Rapaport

❮ Previous
Next ❯

Citations

Jun 19, 1990·Klinische Wochenschrift·B EberW Klein
Oct 1, 1992·Italian Journal of Neurological Sciences·S SeveriM Felici
Mar 1, 1993·Italian Journal of Neurological Sciences·S SeveriA Miele
May 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·M Greaves
Aug 1, 1993·Postgraduate Medical Journal·R A AshersonN Futrell
Jan 1, 1991·Rheumatology International·A P van Dam
Dec 14, 2011·Current Rheumatology Reports·Jeffrey S Dlott, Robert A S Roubey
Dec 13, 2012·The International Journal of Neuroscience·Mohamad GoldustElham Rezaee
Aug 2, 2006·Rheumatic Diseases Clinics of North America·Giovanni SannaMaria Jose Cuadrado
Aug 30, 2005·Annals of the New York Academy of Sciences·Giovanni SannaGraham R V Hughes
May 28, 2010·Arthritis Care & Research·Mollie DahlgrenJohn H Stone
Jul 13, 2004·European Journal of Internal Medicine·Christos E. Lampropoulos, Graham R.V. Hughes
Dec 27, 2007·Yonsei Medical Journal·Penka A Atanassova
Apr 25, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·M H EllisE Kott
Apr 1, 1991·The American Journal of Medicine·M L OlsenN B Warner
Jun 1, 1992·Acta Neurologica Scandinavica·M VrethemJ E Olsson
Oct 6, 2017·Frontiers in Cardiovascular Medicine·Rayan Jo RachwanRachoin Rachoin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.