Lupus glomerulonephritis revisited 2004: autoimmunity and end-organ damage

Scandinavian Journal of Immunology
Harini BagavantS M Fu

Abstract

Histopathology of the kidney and clinical presentation are critical factors in the diagnosis of immune-mediated glomerulonephritis (GN). The histological manifestations of glomerular injury are shared by multiple underlying mechanisms. Work from our laboratory and from other investigators shows that antinuclear, antihistone or anti-dsDNA antibodies are neither required nor sufficient for development of lupus GN. In addition, antibody to dsDNA can be generated by mechanisms other than loss of tolerance to chromatin. Genetic analyses demonstrate that although there is some interaction between autoantibody production and renal disease, the phenotypes are regulated by distinct genetic intervals. Furthermore, renal failure is not an essential outcome of the immune-complex deposition and proliferative lupus GN. These data are also supported by published studies from systemic lupus erythematosus (SLE) patients. The immune regulation of lupus GN is distinct from other organ-specific diseases and not influenced by CD25(+) or NK1.1(+) regulatory T cells. Thus, fatal GN may depend upon a kidney-reactive T-cell response that, in turn, may be regulated by gender and intrinsic end-organ factors. The data discussed in this review call for a r...Continue Reading

References

Oct 1, 1992·Kidney International·C Díaz GalloV R Kelley
Jun 1, 1992·Kidney International·D V VlahakosM P Madaio
Jul 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K A Nath
Jan 1, 1990·Kidney International·E AlexopoulosJ S Cameron
Feb 1, 1985·The Journal of Clinical Investigation·W H ReevesH G Kunkel
Feb 1, 1973·Kidney International·V AgnelloH G Kunkel
Oct 1, 1967·The Journal of Experimental Medicine·D KofflerH G Kunkel
Jul 1, 1971·The Journal of Experimental Medicine·D KofflerH G Kunkel
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D E FisherH G Kunkel
Sep 1, 1983·The American Journal of Medicine·H A AustinJ E Balow
Apr 1, 1995·Immunological Reviews·C G DrakeB L Kotzin
May 1, 1993·The Journal of Experimental Medicine·C MohanS K Datta
May 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L MorelE K Wakeland
Jun 1, 1996·The Journal of Experimental Medicine·A KaliyaperumalS K Datta
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y WangL A Matis
Aug 1, 1996·The Journal of Experimental Medicine·M AsanoS Sakaguchi
Sep 15, 1996·The Journal of Clinical Investigation·J B LefkowithM Gourley
Nov 1, 1996·Journal of the American Society of Nephrology : JASN·R MukherjeeA M Jevnikar
Feb 15, 1997·The Journal of Clinical Investigation·B P TsaoJ I Rotter
Apr 15, 1997·The Journal of Clinical Investigation·S L PengJ Craft
Feb 7, 1998·The Journal of Clinical Investigation·D BalomenosA N Theofilopoulos
Mar 21, 1998·The Journal of Clinical Investigation·S VidalA N Theofilopoulos
Mar 20, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S F MassengillJ W Sleasman
May 23, 1998·Annual Review of Immunology·T J Vyse, B L Kotzin
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·K L MoserJ B Harley
Jun 22, 1999·The Journal of Clinical Investigation·C MohanE K Wakeland
Jul 9, 1999·Current Topics in Microbiology and Immunology·N Ibnou-ZekriS Izui
Jan 13, 2000·Current Opinion in Immunology·E K WakelandL Morel
Jun 3, 2000·Annual Review of Immunology·E M Shevach
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·U S DeshmukhS M Fu
Oct 4, 2000·International Reviews of Immunology·D H Kono, A N Theofilopoulos
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S YamagiwaD A Horwitz
Jun 26, 2001·Journal of the American Society of Nephrology : JASN·Guillermo Pérez DE LemaDetlef Schlöndorff
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B R LawsonA N Theofilopoulos

❮ Previous
Next ❯

Citations

Feb 14, 2008·Clinical Reviews in Allergy & Immunology·Ram MayaYehuda Shoenfeld
Aug 12, 2005·Current Opinion in Rheumatology·Harini Bagavant, Shu Man Fu
Apr 16, 2013·Biochemistry. Biokhimii︠a︡·V N BunevaG A Nevinsky
Nov 2, 2006·PLoS Medicine·Graciela S AlarcónUNKNOWN PROFILE Study Group
May 8, 2014·Journal of Immunology Research·Sonal Mehra, Marvin J Fritzler
Aug 26, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jera JerucDusan Ferluga
Jul 28, 2006·Molecular Immunology·Roelof Flierman, Mohamed R Daha
Mar 15, 2006·Seminars in Nephrology·Neerja AgrawalIan R Rifkin
Aug 8, 2006·Autoimmunity Reviews·Umesh S DeshmukhShu Man Fu
Aug 13, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Umesh S DeshmukhShu Man Fu
Mar 11, 2008·International Immunopharmacology·Bor-Show TzangTsai-Ching Hsu
May 5, 2007·Nature Medicine·Roberto BaccalaArgyrios N Theofilopoulos
Apr 21, 2006·Journal of the American Society of Nephrology : JASN·Peter G Tipping, Stephen R Holdsworth
Jun 24, 2008·Journal of Immunotoxicology·Jean C PfauDavid J Blake
Mar 10, 2009·The Korean Journal of Internal Medicine·Hyoun Ah KimChang Hee Suh
Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jared M OdegardJoe Craft
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaodong HeDaniel C Bullard
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenneth J ScalapinoDavid I Daikh
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Harini Bagavant, Kenneth S K Tung
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brendan M GilesSusan A Boackle
Nov 9, 2006·Ultrastructural Pathology·John Hicks, Daniel C Bullard
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zeguo ZhaoChaim Putterman
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julieta GentilettiPaul J Christner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

© 2022 Meta ULC. All rights reserved