Lupus nephritis reoccurs following transplantation in the lupus prone mouse

Lupus
P HamarU Heemann

Abstract

The incidence and pathomechanism of recurrent lupus nephritis (RLN) after transplantation is not clearly understood. Burning out of the autoimmune process or local immunoregulatory mechanisms in the kidney may be responsible for the low incidence of recurrence. These mechanisms cannot be investigated in human subjects, due to post-transplant immunosuppression. To investigate the pathomechanisms of RLN, male and female kidneys were transplanted from FAS deficient lupus prone (LPR) or control (FAS intact) MRL mice into either LPR or MRL recipients. Urinary protein and blood urea were assessed. Double negative (DN) lymphocyte proliferation was determined by flow cytometry. Two months after transplantation inflammatory infiltration of the glomerular, vascular and interstitial compartments were determined. Renal function as demonstrated by blood urea levels was normal in MRL recipients, but elevated in LPR recipients, independent of the donor strain. Paralleling functional results, inflammatory infiltration was mild or absent in MRL recipients of MRL grafts, and mild to moderate in MRL recipients of LPR grafts, suggesting that kidney removal from the autoimmune (LPR) environment significantly reduced inflammation. Graft infiltration...Continue Reading

References

Jan 1, 1988·International Archives of Allergy and Applied Immunology·S IgarashiK Kano
Nov 1, 1985·Clinical Immunology and Immunopathology·V E Kelley, J B Roths
Jan 1, 1984·Archives of Dermatological Research·F FurukawaY Hamashima
Jul 1, 1996·The American Journal of Medicine·C F Mojcik, J H Klippel
Feb 7, 1998·The Journal of Clinical Investigation·D BalomenosA N Theofilopoulos
Sep 15, 2001·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·V LászlóA Falus
Jul 31, 2002·International Immunology·Roy D BloomMichael P Madaio
Mar 18, 2003·Transplantation·Simin GoralJ Harold Helderman
May 13, 2003·Microsurgery·Minghui WangUwe Heemann
Apr 30, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gabriella MoroniClaudio Ponticelli
Aug 26, 2006·Nature Clinical Practice. Nephrology·Francis Weng, Simin Goral
Oct 3, 2006·Current Opinion in Immunology·Virginia PascualJacques Banchereau
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul A BlairClaudia Mauri
Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jared M OdegardJoe Craft
Jun 6, 2009·Journal of Internal Medicine·A Rosen, L Casciola-Rosen

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Citations

Oct 19, 2010·Mediators of Inflammation·Maria D Sanchez-NiñoAlberto Ortiz

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