Lupus nephritis: varying complement-fixing properties of immunoglobulin G antibodies to antigens of cell nuclei

T Tojo, G J Friou


Relative complement-fixing activity of antibodies to nuclear antigens, including DNA, were determined in serums of 15 patients with, and 65 patients without, active lupus nephritis, by comparing titers obtained in two methods. High complement-fixing activity of antibody was found in the nephritis group and low activity in the others. Results with immunoglobulin G fractions were similar.


Dec 1, 1969·Arthritis and Rheumatism·J MolinaG J Friou
Sep 1, 1970·Arthritis and Rheumatism
Mar 1, 1972·Arthritis and Rheumatism·P H SchurN Rothfield
Nov 1, 1974·Arthritis and Rheumatism·M E Gershwin, A D Steinberg
Jan 1, 1978·Journal of Immunological Methods·T SasakiK Yoshinaga
Sep 25, 1969·The New England Journal of Medicine·T PincusN Talal
May 8, 1998·The New England Journal of Medicine·B H Hahn
Jul 20, 2012·Current Opinion in Rheumatology·Onkar P Kulkarni, Hans-Joachim Anders
Dec 1, 1977·The Journal of Clinical Investigation·J B PennebakerM Ziff
Jul 5, 2012·Clinical & Developmental Immunology·Susan Yung, Tak Mao Chan
Jan 10, 2014·Seminars in Immunopathology·Hans-Joachim Anders, Agnes B Fogo
Jan 1, 1984·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K S ShapiroA S Levey
Aug 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M SuzukiK Yoshinaga
Nov 1, 1986·Kidney International·A D Steinberg
Aug 5, 2008·Neuroscience·Daniel P Ankeny, Phillip G Popovich
Oct 1, 1991·The American Journal of Medicine·T SasakiK Yoshinaga
Mar 1, 1973·The Journal of the Maine Medical Association·S A Sokol
Nov 1, 1976·Seminars in Arthritis and Rheumatism·F Fernandez-Madrid, M Mattioli
Mar 1, 1985·Clinical Immunology and Immunopathology·R R ValleP H Schur
Aug 1, 1978·Clinical Immunology and Immunopathology·R D Sontheimer, J N Gilliam
Sep 1, 1982·Scandinavian Journal of Immunology·T SasakiK Yoshinaga
May 1, 1971·The Journal of Pediatrics·A J Ammann, R Hong
Aug 10, 2013·Journal of the American Society of Nephrology : JASN·Maciej Lech, Hans-Joachim Anders
Jan 1, 1970·Arthritis and Rheumatism·C M Brunner, J S Davis
Apr 30, 1998·Immunological Investigations·E H BeutnerR L Rubin
Jun 1, 1976·Acta Pathologica Et Microbiologica Scandinavica. Section C, Immunology·A Wiik
Apr 24, 2003·International Journal of Dermatology·Ernst H Beutner
Aug 1, 2008·Arthritis and Rheumatism·Mario H CardielLJP 394-90-09 Investigator Consortium

Related Concepts

Immunofluorescence Assay
Bright Disease
Cell Nucleus
Rheumatoid Arthritis
Fluorescent Antinuclear Antibodies
Gamma globulin

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.