Lupus nephritis: varying complement-fixing properties of immunoglobulin G antibodies to antigens of cell nuclei

Science
T Tojo, G J Friou

Abstract

Relative complement-fixing activity of antibodies to nuclear antigens, including DNA, were determined in serums of 15 patients with, and 65 patients without, active lupus nephritis, by comparing titers obtained in two methods. High complement-fixing activity of antibody was found in the nephritis group and low activity in the others. Results with immunoglobulin G fractions were similar.

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Related Concepts

Immunofluorescence Assay
Autoantibodies
Nephritis
Hepatitis
Bright Disease
Cell Nucleus
Rheumatoid Arthritis
Fluorescent Antinuclear Antibodies
Antigens
Gamma globulin

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