Lupus pathogenesis: role of IgE autoantibodies

Cell Research
Jagadeesh Bayry

Abstract

IgE is commonly known for its role in the Th2 responses, protection against helminth parasites and pathogenesis of allergy. A recent report shows that IgE autoantibodies to dsDNA plays a major role in the pathogenesis of lupus nephritis by exacerbating the interferon-α responses in plasmacytoid dendritic cells.

References

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Nov 26, 2014·Nature Reviews. Rheumatology·Meenu Sharma, Jagadeesh Bayry
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