Lupus: The microbiome angle

Immunobiology
Rabi YacoubJessy J Alexander

Abstract

Microbiota consists of more than 1014 microorganisms that inhabit different areas of the body including the gastrointestinal tract, mainly the mouth and gut. It includes viruses, fungi, protozoa, archaea and bacteria. The microbiota interacts closely with host leading to a dynamic relationship that results in the biological effects observed. Its diverse genetic material (microbiome) interacts closely with the host immune system and cells, and therefore is closely associated with inflammation, immune tolerance, adaptive immunity and autoimmune diseases. Bacterial microbiota, which is the mostly studied lives in harmony with the host and maintains a symbiotic relationship. Therefore it plays an important role in immunological, metabolic, and neurological aspects and thereby the well-being of the host. Alteration of the homeostatic environment or the dynamic balance of microorganisms can result in dysbiosis or disease. However, does dysbiosis cause disease, aggravate disease or is the result of the disease remains to be defined, it could be a bit of all three factors. More recently, a number of studies demonstrate that these microorganisms could contribute to disease. Alteration of the tightly balanced composition of bacterial mic...Continue Reading

Citations

Dec 13, 2018·Experimental Biology and Medicine·Rabi YacoubJaime Uribarri
Jun 25, 2019·The American Journal of Gastroenterology·Natalie C KnoxCharles N Bernstein
Sep 4, 2019·Infection·Muhammad Bilal Abid, Calvin J Koh
Sep 24, 2020·Mediators of Inflammation·Huihui XuQingdong Guan
Nov 14, 2019·International Journal of Molecular Sciences·Fulvia CeccarelliFabrizio Conti
Aug 8, 2018·Nutrients·Leila Abdelhamid, Xin M Luo
Jan 31, 2020·Frontiers in Immunology·M Firoze Khan, Hui Wang
Jun 28, 2020·Neuroscience Bulletin·Sophie OuabbouMing Tsuang
Apr 4, 2019·Journal for Immunotherapy of Cancer·Muhammad Bilal Abid
Nov 28, 2019·Journal of Immunology Research·Huihui XuHongyan Zhao
Jul 19, 2020·Arthritis Research & Therapy·Ting Zhang, Chandra Mohan
Jul 16, 2021·British Journal of Cancer·K A LeeT D Spector

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