Lurasidone: an atypical antipsychotic for schizophrenia

The Annals of Pharmacotherapy
Vineeta RisboodMatthew A Fuller

Abstract

To provide a clinical overview of the antipsychotic lurasidone. Articles were identified by searching the MEDLINE, PubMed, Cochrane Library, and EBSCO databases (through February 2012) using the key word lurasidone. The manufacturer provided information on unpublished Phase 2 and 3 trials. The Clinicaltrials.gov database was reviewed for the status of ongoing and upcoming trials. All clinical trials lasting longer than 3 weeks and published in the English language were selected for review. Additional documentation, including the product dossier, package insert, and poster presentations supplied by the publisher, was also evaluated. Lurasidone hydrochloride is an atypical antipsychotic that is approved for the treatment of schizophrenia. It is under investigation for treatment of bipolar I disorder. It should be administered with food, is pregnancy category B, is contraindicated for coadministration with strong CYP3A4 inducers and inhibitors, and requires dose adjustments with certain medications and in renal and hepatic impairment. Like other atypical antipsychotics, lurasidone possesses dopamine D(2) and serotonin 5-HT(2A) antagonism but exhibits little affinity for histamine H(1), α(1)-adrenergic, or cholinergic M1 receptors....Continue Reading

References

Feb 16, 2016·The Psychiatric Clinics of North America·Marla F WaldDrue Clark
Jan 31, 2015·Expert Opinion on Investigational Drugs·Mauro Giovanni CartaJoseph R Calabrese
Jul 15, 2015·Chemical Society Reviews·Tegan P Stockdale, Craig M Williams
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Citations

Jun 7, 2005·Behavioural Brain Research·G Perez-Garcia, A Meneses
Sep 21, 2005·The New England Journal of Medicine·Jeffrey A LiebermanClinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators
Sep 28, 2007·Mini Reviews in Medicinal Chemistry·Valeria PittalàGiuseppe Romeo
Apr 2, 2009·Psychopharmacology·Atheir I AbbasBryan L Roth
Sep 29, 2009·Expert Opinion on Investigational Drugs·Jonathan M MeyerEdward Schweizer
Jun 17, 2011·The American Journal of Psychiatry·Herbert Y MeltzerAntony D Loebel

Related Concepts

Taurochenodeoxycholate 6alpha-hydroxylase Activity
Histamine Measurement
Metabolic Process, Cellular
Antipsychotic Effect
Atypical Antipsychotic [EPC]
Schizophrenia
Serotonin Measurement
Serotonin
Antagonist Muscle Action
Hepatic Impairment

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