Lurasidone in Children and Adolescents: Systematic Review and Case Report

Journal of Child and Adolescent Psychopharmacology
Jonathan ChanningSamuele Cortese

Abstract

To perform a systematic review of studies of lurasidone in children and/or adolescents and to present a case report aimed to add further insights into its use in clinical practice with youth. We searched the following databases for empirical studies, of any design, focusing on the pharmacokinetics, efficacy, or safety of lurasidone in children and/or adolescents: Pubmed (Medline), OVID (PsycInfo, EMBASE+EMBASE classic, OVID Medline), Web of Knowledge, and ClinicalTrials.gov (last search January 23, 2018). From a pool of 301 potentially relevant references, we retained 12 pertinent studies (reported in 28 references), including 1 pharmacokinetics study, 1 double blind randomized controlled trial (RCT) for bipolar depression (BD) with 1 related interim analysis study of its extension phase and 1 related external posterior predictive check study, 1 double blind RCT for schizophrenia with 3 related interim analyses of its extension phase, 1 RCT and 1 case report for autism spectrum disorder, and 2 open-label studies focusing on a variety of disorders. Overall, these studies show that lurasidone is significantly more efficacious than placebo, with moderate effect sizes, and is well tolerated for BD and schizophrenia in youth. Publis...Continue Reading

References

Apr 21, 2010·The Journal of Pharmacology and Experimental Therapeutics·Tadashi IshibashiMitsutaka Nakamura
Dec 7, 2013·Behavioural Brain Research·Takeshi MuraiMutsuo Taiji
Aug 20, 2014·Journal of Child and Adolescent Psychopharmacology·Presenters Hun MillardDiscussant Barbara J Coffey
Dec 15, 2015·Journal of Autism and Developmental Disorders·Antony LoebelRobert L Findling
Apr 14, 2016·PharmacoEconomics·Krithika RajagopalanAntony Loebel
Mar 8, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael OstacherAntony Loebel
May 6, 2017·Journal of Child and Adolescent Psychopharmacology·Robert GoldmanRobert L Findling
Nov 28, 2017·Journal of the American Academy of Child and Adolescent Psychiatry·Melissa P DelBelloAntony Loebel

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Citations

Jul 14, 2020·Expert Opinion on Drug Safety·Laura OrsoliniUmberto Volpe
Jan 27, 2021·Health and Quality of Life Outcomes·Gian Loreto D'AlòUNKNOWN ISACAGuideline Working Group
Mar 25, 2021·Journal of Pharmacy Practice·Tom B MoleWai Chen
Jan 19, 2022·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A V Goryunov

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Methods Mentioned

BETA
sedation

Clinical Trials Mentioned

NCT01620060
NCT02046369
NCT01911429
NCT01911442
NCT01731119

Software Mentioned

PRISMA

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