Lurasidone reverses MK-801-induced impairment of learning and memory in the Morris water maze and radial-arm maze tests in rats

Behavioural Brain Research
Takeshi EnomotoAkira Ito


We have previously shown that lurasidone, a novel atypical antipsychotic, potently reverses learning impairment induced by the N-methyl-D-aspartate receptor antagonist MK-801 in the rat passive avoidance test. However, the effects of lurasidone in other learning and memory tasks remain to be investigated. We investigated the effects of lurasidone and other marketed antipsychotics (risperidone, clozapine, aripiprazole, and haloperidol) on MK-801-induced impairment of learning and memory in the Morris water maze (MWM) and radial-arm maze (RAM) tests in rats. Learning and memory impairment in the MWM test, as measured by escape latency, escape distance, and diving behavior, and in the RAM test, as measured by reference and working memory errors, was induced by MK-801 (i.p.) at doses of 0.15 and 0.2 mg/kg, respectively. In the MWM test, lurasidone (1 and 3 mg/kg p.o.) potently reversed MK-801-induced learning impairment. In the RAM test, lurasidone (1 and 3 mg/kg p.o.) potently reversed MK-801-induced reference memory impairment and moderately but not significantly attenuated MK-801-induced working memory impairment. Risperidone (0.3 and 1mg/kg p.o.), clozapine (3 and 10 mg/kg p.o.), aripiprazole (0.3 and 1mg/kg p.o.), and haloperi...Continue Reading


Dec 25, 2012·CNS Drugs·Mark Sanford
Mar 5, 2013·Behavioural Brain Research·Takeshi MuraiKazuhito Ikeda
Aug 16, 2011·Acta Pharmacologica Sinica·Jaqueline Nascimento PicadaPatrícia Pereira
Jun 29, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Masakuni HoriguchiHerbert Y Meltzer
Jun 8, 2012·Drug Design, Development and Therapy·Norio Yasui-Furukori
Aug 16, 2011·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·David R P Guay
Jan 29, 2013·Expert Opinion on Pharmacotherapy·Peter Paul De DeynDebby Van Dam
May 9, 2012·Expert Opinion on Pharmacotherapy·Roger S McIntyreJeanette M Jerrell
May 2, 2014·Expert Review of Neurotherapeutics·Cecilio AlamoPilar García-García
Jul 11, 2013·Expert Opinion on Drug Discovery·Frank I Tarazi, Marco A Riva
Sep 29, 2009·Expert Opinion on Investigational Drugs·Jonathan M MeyerEdward Schweizer
Feb 1, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tomoko HorisawaMutsuo Taiji
Jan 10, 2012·Behavioural Brain Research·Ming-Hong HsiehFu-Ying Wu
Sep 24, 2015·Pharmacology, Biochemistry, and Behavior·Pelin TanyeriBekir Faruk Erden
Dec 24, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Alessia LuoniMarco A Riva
Aug 16, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Kyeong-Ryoon LeeTae-Sung Koo
Sep 17, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Philip D HarveyAntony Loebel
Apr 12, 2015·European Journal of Pharmacology·Kazuo YamadaYukio Ichitani
Mar 26, 2015·Behavioural Brain Research·Satoko BabaKazuhito Ikeda
Feb 19, 2013·Neuropharmacology·Lindsay N CatesPeter B Hedlund

Related Concepts

Histamine Measurement
Antipsychotic Effect
Atypical Antipsychotic [EPC]
Memory Loss
Behavior, Animal
Other antipsychotics in ATC
Assay OF Haloperidol
Reaction Time

Related Feeds

Antipsychotic-Induced Weight Gain

Antipsychotic-induced weight gain (aiwg) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. Here are the latest discoveries pertaining to AIWG.


This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here