Lutathera® : The First FDA- and EMA-Approved Radiopharmaceutical for Peptide Receptor Radionuclide Therapy

Pharmaceuticals
Ute Hennrich, Klaus Kopka

Abstract

As the first radiopharmaceutical for Peptide Receptor Radionuclide Therapy (PRRT), Lutathera® was approved by the EMA in 2017 and the FDA in 2018 for the treatment of somatostatin receptor (SSTR) positive gastroenteropancreatic neuroendocrine tumors. Using the concept of PRRT, Lutathera® combines the radionuclide 177Lu with the somatostatin analogue DOTA-TATE, thus delivering ionizing radiation specifically to tumor cells expressing somatostatin receptors. As a result, DNA single- and double-strand breaks are provoked, in case of double-strand breaks leading to cell death of the tumor and its SSTR-positive lesions.

References

Jun 3, 2004·Nature Reviews. Drug Discovery·Diane E MilenicMartin W Brechbiel
Nov 10, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Martin W Brechbiel
Dec 10, 2009·Endocrine-related Cancer·Dik J KwekkeboomEric P Krenning
Mar 1, 2011·Nuclear Medicine and Molecular Imaging·Young Chul KimJae-Gol Choe
Feb 25, 2015·Cancer Biotherapy & Radiopharmaceuticals·Ashutosh DashFurn F Russ Knapp
Apr 17, 2015·BioMed Research International·Caiyun Xu, Hong Zhang
Jan 12, 2017·The New England Journal of Medicine·Jonathan StrosbergUNKNOWN NETTER-1 Trial Investigators
Apr 15, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Uwe HaberkornClemens Kratochwil
Sep 3, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Rachel Levine, Eric P Krenning
Oct 28, 2017·Nuclear Medicine and Biology·Heinz H CoenenAlbert D Windhorst
Nov 18, 2017·Radiation and Environmental Biophysics·Mohammad AbuqbeitahKerim Sönmezoğlu
Jan 14, 2018·Journal of Labelled Compounds & Radiopharmaceuticals·Heinz H CoenenAlbert D Windhorst
Sep 5, 2018·The British Journal of Radiology·J Harvey Turner

❮ Previous
Next ❯

Citations

Mar 12, 2020·Expert Review of Medical Devices·Luca FilippiOreste Bagni
Mar 21, 2020·Clinical Journal of Oncology Nursing·Adria Myers, Holly Chitwood
May 21, 2020·Pancreas·Alan G HarrisM Sue OʼDorisio
May 28, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Lily LiChris Orvig
Sep 12, 2020·Nanomedicine·Neha MehrotraHarpal Singh
Jul 21, 2020·Cancer Gene Therapy·Yingnan SiXiaoguang Margaret Liu
Oct 6, 2020·Frontiers in Oncology·Charles A KunosMichael A McDonald
Jul 17, 2020·Nanomaterials·Agnieszka Majkowska-PilipAleksander Bilewicz
Sep 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Romain EychenneNicolas Lepareur
Mar 7, 2020·Pharmaceuticals·Ute Hennrich, Martina Benešová
Jun 3, 2020·International Journal of Molecular Sciences·Andrea CiminiOrazio Schillaci
Oct 30, 2020·Drug Delivery·Shentian WuRalph Santos-Oliveira
Nov 3, 2020·Frontiers in Molecular Biosciences·Jay V ShahVidya Ganapathy
Nov 22, 2020·International Journal of Molecular Sciences·Mackenzie E MaloEkaterina Dadachova
Feb 19, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Giacomo PirovanoThomas Reiner
Dec 22, 2020·Nihon Hoshasen Gijutsu Gakkai zasshi·Kohei HanaokaHiroyuki Tsushima
Jan 17, 2021·Annals of Surgical Oncology·Catherine G TranJames R Howe
Feb 4, 2021·Journal of Medicinal Chemistry·Rajendra P BandariCharles J Smith
Feb 16, 2021·Frontiers in Chemistry·Amreen KhanRohit Srivastava
Mar 4, 2021·Journal of Nanoscience and Nanotechnology·Mariano Andrea ScorciapinoIgor Bodrenko
Mar 2, 2021·Nuclear Medicine and Molecular Imaging·Redmond-Craig AndersonHossein Jadvar
Jun 6, 2020·PET Clinics·Lorenzo NardoAbass Alavi
Apr 2, 2021·ChemMedChem·Natalia Herrero ÁlvarezJason S Lewis
Jul 6, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·C Shaun LovelessSuzanne E Lapi
May 25, 2021·Nuclear Medicine and Biology·Shishu Kant SumanArchana Mukherjee
Jun 23, 2021·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Jonathan SiikanenThuy A Tran
Jul 19, 2021·European Journal of Radiology·Fulvio ZaccagnaFerdia A Gallagher
Jul 30, 2021·Current Opinion in Chemical Biology·Dora Mugoli ChigohoSophie Hernot
Aug 3, 2021·Trends in Pharmacological Sciences·Yi-Shen ZhuJiayi Lv
Apr 7, 2020·Molecular Pharmaceutics·Zhihao ZhaHank F Kung
Dec 2, 2021·Metallomics : Integrated Biometal Science·Mariane Le FurMaryline Beyler

❮ Previous
Next ❯

Methods Mentioned

BETA
electron

Software Mentioned

NETSPOT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.