Luteal phase hormonal profile in prediction of pregnancy outcome after assisted reproduction

European Journal of Obstetrics, Gynecology, and Reproductive Biology
K Vicdan, A Zeki Isik

Abstract

The clinical efficacy of luteal phase hormones including estradiol and progesterone in the prediction of pregnancy and its outcome in ICSI-ET cycles was evaluated. In 121 ICSI-ET cycles, serial estradiol and progesterone levels were measured in the luteal phase. The day of ovum pick-up was designated as day 0. All the patients had luteal support with vaginal progesterone suppositories after embryo transfer (ET). Serial estradiol measurements were performed on days 8, 11 and 13 and progesterone level on day 11. A single dose of hCG was given for corpus luteum rescue 5000 IU, if day 8 estradiol level <200pg/ml; 2000IU, if estradiol between 200 and 800pg/ml; no hCG if estradiol level >800pg/ml). On day 15, beta-hCG level was measured to detect pregnancy and if positive, injected on day 17. Fifty-seven pregnancies were achieved in 121 cases after ET (47%). Clinical pregnancy rate and ongoing pregnancy rate per ET were 37.1 and 30%, respectively. While there was no difference between progesterone levels measured on day 11, estradiol levels on days 11 and 13 were significantly higher in women who became pregnant. In 40 patients taking only progesterone and in 81 cases taking hCG plus progesterone, estradiol levels on days 11 and 13 w...Continue Reading

References

Feb 1, 1986·The Australian & New Zealand Journal of Obstetrics & Gynaecology·J L YovichA E Bolton
Oct 1, 1993·Obstetrics and Gynecology·J F Peipert, P J Sweeney
Feb 7, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·K VicdanA Z Işik

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Citations

Feb 20, 2013·SpringerPlus·Ibrahim A AbdelazimMohamed Elsherbiny
Dec 29, 2015·Fertility and Sterility·Alexis P MelnickSteven D Spandorfer
Sep 9, 2004·Reproductive Biomedicine Online·R R GrebL Kiesel
Dec 22, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Umit GoktolgaIskender Baser
Apr 20, 2004·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Michael F CostelloStephen Steigrad
Jun 19, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Barbara SonntagRobert R Greb
Apr 30, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Panagiotis BakasNikolaos Vlahos

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