Abstract
Many coronary artery disease (CAD) patients exhibit chronic low-grade inflammation. Carotenoids are anti-oxidants with potential anti-inflammatory properties. Here, we first assessed relationships between interleukin (IL)-6 and individual carotenoids in plasma from CAD patients. Based on the results, we proceeded to assess anti-inflammatory effects of one carotenoid, lutein, in peripheral blood mononuclear cells (PBMCs) from CAD patients. Lutein + zeaxanthin (isomers with lutein being dominant), β-cryptoxanthin, lycopene, α- and β-carotene and IL-6 were measured in plasma from 134 patients with stable angina (SA) and 59 patients with acute coronary syndrome. In 42 patients, plasma measurements were also performed 3 months after coronary intervention. PBMCs from SA patients were pre-treated with lutein (1, 5 and 25 μM) for 24 h followed by 24 h incubation ± lipopolysaccharide (LPS). Cell pellets were collected for IL-6, IL-1β and TNF mRNA and intracellular lutein. Cytokine secretion was measured in cell media. Only lutein + zeaxanthin were inversely correlated with IL-6 in SA patients at baseline (r = -0.366, p < 0.001) and follow-up (r = -0.546, p < 0.001). Ex vivo, lutein was taken up by PBMCs from SA patients in a dose- and t...Continue Reading
Citations
Apr 27, 2018·European Clinical Respiratory Journal·M KentsonH L Persson
Jan 18, 2018·Future Oncology·Jingzhi ChangShanfeng Zhang
Aug 15, 2019·Nutrition Research Reviews·Grainne ScanlonDaniel McCartney
Apr 17, 2018·Advances in Nutrition·Sara E Thomas, Elizabeth J Johnson
May 31, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L M CoheleyR D Lewis
May 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bee Ling Tan, Mohd Esa Norhaizan
Sep 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ren LiuDong-Sun Lee
Aug 23, 2019·Journal of Natural Medicines·Yuki ManabeTatsuya Sugawara
Sep 17, 2020·Animals : an Open Access Journal From MDPI·Abdallah Tageldein MansourAhmed Elsayed Sallam
Oct 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Diego Estrada-LunaGabriel Betanzos-Cabrera
Sep 21, 2018·Nutrients·Silvio BuscemiGiulio Marchesini
Aug 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Litao WangQibao Wang
Oct 13, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fatemeh Hajizadeh-SharafabadAli Tarighat-Esfanjani
Feb 10, 2021·BMC Complementary Medicine and Therapies·E BandariyanA Ahmadi
Sep 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hidde P van SteenwijkAlie de Boer
Aug 20, 2019·Physiology & Behavior·Nicole T StringhamJames M Stringham
May 1, 2021·International Journal of Molecular Sciences·Lucía GuevaraJosé M Palma
Jun 3, 2021·Redox Biology·Youming ChenWei Chang
Jun 11, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Saikat MitraKannan Rr Rengasamy
Sep 29, 2020·ACS Omega·Hideki KandaMotonobu Goto
Aug 27, 2021·Journal of Biochemical and Molecular Toxicology·Maha AbdelmonemMai A Abd-Elmawla