Lutein nanocrystals as antioxidant formulation for oral and dermal delivery

International Journal of Pharmaceutics
Khalil MitriRainer H Müller

Abstract

Lutein is a well known antioxidant and anti-free radical used in cosmetic, nutraceutical industry with potential application in pharmaceutics as supportive antioxidant in treatments. As lipophilic molecule it is poorly soluble in water and has a low bioavailability. Lutein nanosuspension was prepared to enhance dissolution velocity, saturation solubility (C(s)), which are major factors determining oral bioavailability and penetration into the skin. High pressure homogenization (HPH) was used to prepare lutein nanosuspension. Particle size was determined by photon correlation spectroscopy (PCS) and laser diffractometry (LD). The lowest PCS diameter obtained was about 429 nm, the LD diameter 90% of 1.2 μm. The zeta potential was about -40 mV in water and -17 mV in the original dispersion medium. The 3 month storage study at different temperatures (4°C, 25°C, 40°C) confirmed physical stability despite the low zeta potential of -17 mV in original surfactant solution. A pronounced increase in saturation solubility by 26.3 fold was obtained for lutein nanocrystals compared to coarse powder. The lutein nanosuspension was converted into pellets and filled into hard gelatin capsules for nutraceutical use, showed a superior in vitro rele...Continue Reading

References

Oct 1, 1993·Journal of Pharmaceutical Sciences·M J SkibicS W Baertschi
May 22, 2001·Archives of Biochemistry and Biophysics·J T Landrum, R A Bone
Mar 11, 2004·The Journal of Investigative Dermatology·Erica H LeeRichard D Granstein
Apr 8, 2004·Toxicology Letters·Alexandra Alves-Rodrigues, Andrew Shao
Jun 5, 2004·Stroke; a Journal of Cerebral Circulation·A Elisabeth HakMeir J Stampfer
Jun 24, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jongwon ShimIh-Seop Chang
Sep 1, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Cornelia M Keck, Rainer H Müller
Feb 5, 2008·International Journal of Pharmaceutics·Veerawat TeeranachaideekulRainer H Müller
Dec 31, 2008·International Journal of Pharmaceutics·Rachmat MauludinCornelia M Keck
Jan 24, 2009·International Journal of Pharmaceutics·Prabhat R MishraCornelia M Keck
Jan 27, 2009·Clinics in Dermatology·Richard L RobertsBrandon Lewis
Jul 15, 2009·International Journal of Pharmaceutics·Sudhir VermaDiane J Burgess
Aug 3, 2010·International Journal of Pharmaceutics·Ranjita Shegokar, Rainer H Müller

Citations

Oct 19, 2013·International Journal of Pharmaceutics·F LaiChiara Sinico
Mar 29, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vivek K PawarManish K Chourasia
Dec 18, 2012·Drug Development and Industrial Pharmacy·Kalle SigfridssonMarie Strimfors
Jun 5, 2015·Critical Reviews in Biotechnology·Azadeh ManayiSeyed Mohammad Nabavi
Aug 8, 2014·Journal of Pharmaceutical Sciences·William Wei Lim ChinRajeev Gokhale
Nov 19, 2015·Journal of Pharmaceutical Sciences·Dhaval A ShahRutesh H Dave
Mar 31, 2015·Journal of Pharmaceutical Sciences·Sharad B MurdandeRutesh H Dave
May 7, 2013·Current Opinion in Solid State & Materials Science·Bo Sun, Yoon Yeo
Aug 15, 2012·Journal of Dietary Supplements·Ranjita Shegokar, Khalil Mitri
Jun 23, 2016·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Kale Mohana Raghava Srivalli, Brahmeshwar Mishra
Apr 26, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Saul Mujica AscencioMaxim E Darvin
May 22, 2016·Drug Delivery and Translational Research·Yaya LeiWenping Wang
Jan 27, 2017·Annual Review of Food Science and Technology·Rohollah SadeghiJozef L Kokini
Jul 28, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Daoxiao ChangWenping Wang
Feb 22, 2018·Expert Opinion on Drug Delivery·Viral PatelTejal Mehta
Oct 19, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xiaoqing MiaoPeng Huang
Feb 16, 2019·Current Pharmaceutical Design·Vishwas P PardhiRahul Shukla
Dec 14, 2018·Current Medicinal Chemistry·F LaiChiara Sinico
Jun 27, 2020·Drug Delivery and Translational Research·Prashantkumar K Parmar, Arvind K Bansal
Aug 28, 2020·Pharmaceutics·Pradeep Kumar BollaJwala Renukuntla
Aug 24, 2018·Pharmaceutics·Maria Rosa GigliobiancoPiera Di Martino
Aug 30, 2019·Current Pharmaceutical Design·Patricia SeverinoEliana B Souto
Aug 28, 2020·Drug Design, Development and Therapy·Parisa Ghasemiyeh, Soliman Mohammadi-Samani
Aug 28, 2020·Journal of Microencapsulation·Pradeep Kumar BollaJwala Renukuntla
Jan 27, 2019·Bioengineering & Translational Medicine·Maria JarvisSamir Mitragotri

Related Concepts

Transdermal Route of Drug Administration
Antioxidant Effect
Microcapsules Drug Delivery System
Drug Formulation Process
Celloidin
Drug Stability
Gel
Membranes, Artificial
Paste Substance
Particle Size

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.