Luteinizing Hormone and Testosterone Levels during Acute Phase of Severe Traumatic Brain Injury: Prognostic Implications for Adult Male Patients

Frontiers in Endocrinology
Alexandre HohlRoger Walz

Abstract

Traumatic brain injury (TBI) is a worldwide core public health problem affecting mostly young male subjects. An alarming increase in incidence has turned TBI into a leading cause of morbidity and mortality in young adults as well as a tremendous resource burden on the health and welfare sector. Hormone dysfunction is highly prevalent during the acute phase of severe TBI. In particular, investigation of the luteinizing hormone (LH) and testosterone levels during the acute phase of severe TBI in male has identified a high incidence of low testosterone levels in male patients (36.5-100%) but the prognostic significance of which remains controversial. Two independent studies showed that normal or elevated levels of LH levels earlier during hospitalization are significantly associated with higher mortality/morbidity. The association between LH levels and prognosis was independent of other predictive variables such as neuroimaging, admission Glasgow coma scale, and pupillary reaction. The possible mechanisms underlying this association and further research directions in this field are discussed. Overall, current data suggest that LH levels during the acute phase of TBI might contribute to accurate prognostication and further prospect...Continue Reading

References

Jul 1, 1992·Metabolism: Clinical and Experimental·V CoiroP Chiodera
Jan 11, 2000·Brain Injury : [BI]·I CernakS Markovic
Jun 7, 2002·The Journal of Clinical Endocrinology and Metabolism·Bertalan Dudás, István Merchenthaler
Apr 24, 2004·Clinical Endocrinology·Amar AghaChristopher J Thompson
Sep 11, 2008·International Journal of Epidemiology·Mary J De SilvaUNKNOWN CRASH Trial Collaborators
Feb 4, 2010·Arquivos brasileiros de endocrinologia e metabologia·Alexandre HohlRoger Walz
Feb 4, 2010·Arquivos brasileiros de endocrinologia e metabologia·Alexandre HohlRoger Walz
Apr 20, 2010·Lancet Neurology·Hester F LingsmaAndrew I R Maas
Jul 5, 2012·CNS Neuroscience & Therapeutics·Maria Emília Rodrigues de Oliveira ThaisRoger Walz
Oct 19, 2012·Neuroimmunomodulation·Flávia Mahatma Schneider SoaresRoger Walz
Jan 19, 2013·Nature Reviews. Neuroscience·Ye XiongMichael Chopp
Apr 23, 2013·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Zandra OlivecronaLars-Owe D Koskinen
Apr 2, 2014·BioMed Research International·André Mendes ArentAlcir Luiz Dafre
Apr 29, 2014·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Alexandre P DiazRoger Walz
May 1, 2015·Critical Care : the Official Journal of the Critical Care Forum·Leonardo LorenteAlejandro Jiménez
Nov 22, 2016·Indian Journal of Endocrinology and Metabolism·K V S Hari KumarM A Khan
Feb 15, 2017·European Journal of Endocrinology·Aoife GarrahyChristopher J Thompson
Feb 22, 2017·Indian Journal of Endocrinology and Metabolism·Pradip P DalwadiPremlata K Varthakavi
May 14, 2017·Journal of Neuroscience Research·Robert Vink
Jul 14, 2017·Frontiers in Neurology·Robert VinkEmma Thornton

❮ Previous
Next ❯

Citations

Feb 14, 2020·International Journal of Psychiatry in Medicine·B Christopher FruehDeborah C Beidel
Jul 23, 2020·Tissue Engineering. Part a·Vimala N BharadwajSarah E Stabenfeldt
Aug 19, 2020·Journal of Neurotrauma·Katherine R GiordanoJonathan Lifshitz
Apr 28, 2021·Archives of Endocrinology and Metabolism·Heraldo Mendes GarmesMarcello Delano Bronstein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

© 2022 Meta ULC. All rights reserved