Luteinizing hormone concentrations after gonadotropin-releasing hormone antagonist administration do not influence pregnancy rates in in vitro fertilization-embryo transfer

Fertility and Sterility
Philippe MervielSerge Uzan

Abstract

To determine the impact of circulating LH concentrations during controlled ovarian hyperstimulation on the outcome of IVF. Retrospective study. University hospital. Two-hundred seventy women who had a short stimulation protocol with GnRH antagonist and ovarian stimulation with recombinant FSH (rFSH). GnRH antagonist and rFSH were administered SC; blood samples were collected on the day of GnRH antagonist administration, 1 day after, and on the day of hCG administration. A threshold of 0.5 IU/L on the day of hCG was chosen to discriminate between women with LH concentrations <or=0.5 IU/L (group A, n = 119) or >0.5 IU/L (group B, n = 151). The two groups were comparable with regard to the clinical parameters. In group A, significantly lower LH concentrations were observed on day 9 of the cycle and on the day of hCG administration. The numbers of oocytes retrieved, embryos obtained, and embryos cryopreserved were significantly higher in group A compared with group B. The proportion of clinical pregnancies was similar in the two groups (21.1% vs. 22.7 % per ET). In GnRH antagonist and rFSH protocols, suppressed serum LH concentrations do not have any influence on the final stages of follicular maturation, pregnancy rates, or outcomes.

References

Nov 1, 1993·The Journal of Clinical Endocrinology and Metabolism·C Y Andersen
Aug 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R E FelberbaumK Diedrich
Jan 1, 1997·Human Reproduction·S G HillierH M Fraser
Apr 4, 1998·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·R AgrawalH S Jacobs
Nov 1, 2000·Human Reproduction·D P LévyZ Rosenwaks

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Citations

Apr 17, 2012·Reproductive Biology and Endocrinology : RB&E·Raffaella DepaloLuigi E Selvaggi
Oct 23, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yu ZhengJihui Ai
Aug 17, 2011·Reproductive Biomedicine Online·George GriesingerBernadette M Mannaerts
Aug 23, 2011·Reproductive Biomedicine Online·Kevin J DoodyBernadette M Mannaerts
Apr 13, 2005·Reproductive Biomedicine Online·J B EngelK Diedrich
Feb 6, 2010·Reproductive Biomedicine Online·Kevin DoodyBernadette Mannaerts
May 22, 2007·Gynécologie, obstétrique & fertilité·M-H HeraudP Merviel
Feb 28, 2006·Fertility and Sterility·Georg GriesingerRicardo Felberbaum
Apr 20, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Gian Mario TiboniFranca Giampietro
Aug 1, 2016·Reproductive Biomedicine Online·Chin-Der ChenShee-Uan Chen
Nov 30, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hai-Yan ZhuYuan Li
Jan 26, 2006·Endocrine Reviews·Nick S MacklonBart C J M Fauser
Nov 26, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Klaus F Bühler, Robert Fischer
Nov 21, 2020·Reproductive Biomedicine Online·Christine I VaitsopoulouBasil C Tarlatzis
Jun 3, 2021·Reproductive Sciences·Jody Paige GohShuling Liu

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