Luteinizing hormone determinations obtained with either a monoclonal and a polyclonal antibody radioimmunoassay and their correlations with clinical findings

Journal of Endocrinological Investigation
P L VenturiniL De Cecco

Abstract

Detection of circulating levels of gonadotropin is fundamental in reproductive physiology and related disorders. The advent of monoclonal antibodies might supply the clinician with faster and more accurate estimates of these hormones. We have evaluated the hormonal determinations provided by a monoclonal assay and those generated from our previous assay, produced by the same manufacturer, based on polyclonal antibodies. Comparison was performed on blood samples collected from volunteers with regular menstruation (n = 51) or patients attending our Clinic. The correlation between data provided by the two assays fluctuated from the almost complete overlap of the physiological menstrual cycle to the striking dissociation of the patients (n = 13) receiving a Gonadotropin Hormone-Releasing Hormone analog for gonadotropin suppression. Intermediate coefficients of correlations were recorded in normal subjects undergoing a Gonadotropin Hormone-Releasing Hormone stimulation test (n = 12) and in patients with functional hypothalamic amenorrhea (n = 19) or polycystic ovarian disease (n = 37). Values obtained with the monoclonal assay tended to be lower than those recorded with the previous system. A closer correlation with the clinical fin...Continue Reading

References

Jul 1, 1989·Clinical Endocrinology·S Franks
Sep 1, 1971·Biochemical and Biophysical Research Communications·M L DufauT Tsuruhara
Apr 1, 1984·The Journal of Clinical Endocrinology and Metabolism·D R MeldrumR J Chang
Jun 1, 1984·The Journal of Clinical Endocrinology and Metabolism·J D VeldhuisM L Dufau
May 1, 1980·Acta Endocrinologica·B M LandgrenE Diczfalusy

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Citations

Sep 5, 2007·Luminescence : the Journal of Biological and Chemical Luminescence·Yingxue ZhangFeng Yang
Nov 1, 1995·Journal of Endocrinological Investigation·F BarbéY Badonnel

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