PMID: 18183790Jan 11, 2008Paper

Luteinizing hormone (LH) and estradiol suppression and growth in girls with central precocious puberty: is more suppression better? Are pre-injection LH levels useful in monitoring treatment?

Journal of Pediatric Endocrinology & Metabolism : JPEM
Gregory J KunzKaren O Klein

Abstract

Girls with central precocious puberty (CPP) are treated with gonadotropin releasing hormone (GnRH) analogues to suppress puberty. Gonadotropin levels are used to monitor treatment, since estradiol is difficult to measure at low levels. The optimal degree of hormonal suppression is still unknown. We hypothesized that in girls treated for CPP, estradiol levels (by ultrasensitive bioassay) would correlate with the rate of skeletal maturation and linear growth velocity. We asked whether predicted height would improve with greater luteinizing hormone (LH) and estradiol suppression. We also compared pre- and post-injection LH levels for monitoring treatment. Thirty girls with CPP were followed for up to 2 years during treatment with leuprolide acetate depot at a dose of 0.3 mg/kg/28 days. We measured LH and estradiol levels, bone age, and growth velocity every 6 months. Estradiol levels were suppressed to below the detection limit in three-quarters of the girls and did not correlate with the rate of skeletal maturation or linear growth. Improvement in predicted height correlated significantly with lower pre-injection LH levels. These girls have some of the lowest estradiol and LH levels, best improvement in predicted height, and leas...Continue Reading

References

Sep 1, 1990·The Journal of Pediatrics·M KreiterL L Levitsky
Feb 1, 1989·The Journal of Pediatrics·P A Lee, J G Page
Dec 1, 1994·The Journal of Clinical Investigation·K O KleinG B Cutler
Apr 1, 1997·The Journal of Steroid Biochemistry and Molecular Biology·G B Cutler
Jan 13, 2004·The Journal of Clinical Endocrinology and Metabolism·Martina WeiseJeffrey Baron

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Citations

Nov 19, 2009·Drug Design, Development and Therapy·Katherine A Lewis, Erica A Eugster
Jan 31, 2009·Clinical Endocrinology·Frances MouatWayne S Cutfield
May 12, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Karen O KleinPeter Bacher
Feb 22, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·David StrichDavid Gillis

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