Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice

Biochimica Et Biophysica Acta
Gemma CasadesusMark A Smith

Abstract

Until recently, the study of hormonal influences in Alzheimer disease was limited to the role of sex steroids. Despite numerous epidemiological studies supporting a protective role for estrogen in Alzheimer disease, recent studies show that estrogen administration in elderly women increases the risk of disease. Reconciling these contradictory reports, we previously hypothesized that other hormones of the hypothalamic-pituitary-gonadal axis, such as luteinizing hormone, may be involved in the onset and development of the disease. In this regard, luteinizing hormone is elevated in Alzheimer disease and is known to modulate amyloidogenic processing of amyloid-beta protein precursor. Therefore, in this study, to evaluate the therapeutic potential of luteinizing hormone ablation, we administered a gonadotropin-releasing hormone analogue, leuprolide acetate, to an aged transgenic mouse model of Alzheimer disease (Tg 2576) and measured cognitive Y-maze performance and amyloid-beta deposition after 3 months of treatment. Our data indicate that luteinizing hormone ablation significantly attenuated cognitive decline and decreased amyloid-beta deposition as compared to placebo-treated animals. Importantly, leuprolide acetate-mediated redu...Continue Reading

References

Jul 1, 1975·Pharmacology, Biochemistry, and Behavior·H Anisman
Jun 1, 1987·American Journal of Medical Genetics·Y H HsiangA C Warren
Jan 1, 1980·Hormone Research·J HasenL R Shapiro
Jul 1, 1996·Neurobiology of Learning and Memory·B J CummingsC W Cotman
Mar 1, 1996·Maturitas·H G Burger
Feb 10, 1998·Hormones and Behavior·J M DanielG P Dohanich
Apr 2, 1999·Psychoneuroendocrinology·H A Bimonte, V H Denenberg
Mar 16, 2000·Journal of Neuroendocrinology·R L BowenR L Atkinson
Feb 13, 2001·Neurobiology of Aging·J JosephM A Smith
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·R B DeMattosD M Holtzman
Feb 12, 2002·Neuroscience and Biobehavioral Reviews·Robert Lalonde
Feb 28, 2002·Hormones and Behavior·Taneli HeikkinenHeikki Tanila
Oct 23, 2002·Journal of Neuroscience Research·Richard L BowenCraig S Atwood
Oct 26, 2002·Free Radical Biology & Medicine·Mark A SmithGeorge Perry
Mar 8, 2003·JAMA : the Journal of the American Medical Association·J Galen BuckwalterValerie C Crooks
Apr 23, 2003·Neurology·V W HendersonL Dennerstein
May 29, 2003·JAMA : the Journal of the American Medical Association·Stephen R RappUNKNOWN WHIMS Investigators
Oct 22, 2003·Clinics in Geriatric Medicine·John E Morley
Nov 25, 2003·Journal of Neuroscience Research·Robert B Gibbs, Rachel Gabor
Jan 28, 2004·Neurology·Victor W Henderson, Eva Hogervorst
Jan 30, 2004·Neurobiology of Aging·Elena K HoskinRichard Mayeux
Jul 9, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Donna M WilcockDave Morgan
Sep 24, 2004·Current Drug Targets. CNS and Neurological Disorders·Gemma CasadesusMark A Smith
Oct 19, 2004·Experimental Gerontology·Taneli HeikkinenHeikki Tanila
Feb 22, 2005·Cellular and Molecular Life Sciences : CMLS·G CasadesusM A Smith

❮ Previous
Next ❯

Citations

Dec 6, 2011·Age·James A YonkerCraig S Atwood
Jul 31, 2013·Neuropharmacology·R AnandAbbas Ali Mahdi
Feb 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Eun-Jin YangDarcy B Kelley
Jul 12, 2011·Therapeutic Advances in Chronic Disease·Jeremy G StoneMark A Smith
Sep 26, 2012·Source Code for Biology and Medicine·Bhaskar DuttaJaques Reifman
Dec 7, 2007·Clinical Medicine & Research·Kate M WebberGemma Casadesus
Sep 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Heather A Bimonte-NelsonJoshua S Talboom
Dec 14, 2011·Neural Plasticity·Ignacio González-BurgosLuis Miguel Garcia-Segura
Jun 21, 2006·Expert Review of Neurotherapeutics·Paula I MoreiraGeorge Perry
Nov 1, 2007·Expert Opinion on Investigational Drugs·Andrea C WilsonCraig S Atwood
Oct 6, 2012·General and Comparative Endocrinology·Kanya AnukulthanakornIshwar Parhar
Feb 10, 2010·Journal of Neuropathology and Experimental Neurology·Jing LinZhenmin Lei
Jul 15, 2015·Hormones and Behavior·Jeffrey A BlairGemma Casadesus
Mar 23, 2012·BioFactors·Russell PalmGemma Casadesus
Oct 21, 2015·Frontiers in Endocrinology·Prema Narayan
Jun 3, 2015·Hormones and Behavior·Veronica L Burnham, Janice E Thornton
Apr 13, 2013·Psychoneuroendocrinology·UNKNOWN Sex On Brain European Research Group – SOBERIra Ronit Hebold Haraldsen
Feb 27, 2016·Phytotherapy Research : PTR·Kanya AnukulthanakornSuchinda Malaivijitnond
Nov 18, 2006·Experimental Gerontology·Francis L Bellino
Mar 23, 2007·Molecular and Cellular Endocrinology·Gemma CasadesusMark A Smith
Jul 31, 2007·Brain Research Reviews·Emily R Rosario, Christian J Pike
Jan 23, 2009·Free Radical Research·Sandra L SiedlakGeorge Perry
Jan 15, 2009·Journal of Clinical Psychopharmacology·David Q Beversdorf, Michael J Tomasi
May 12, 2009·Neurobiology of Aging·Mei YueChristopher Janus
Oct 24, 2012·Molecular Psychiatry·G VerdileUNKNOWN AIBL Research Group
Oct 13, 2006·Antioxidants & Redox Signaling·Anna M BarronRalph N Martins
Jun 18, 2010·Alzheimer Disease and Associated Disorders·Anthony V D'AmicoMing-Hui Chen
Feb 15, 2019·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·M JahanshahiG Bahlakeh
May 22, 2009·Journal of Neurochemistry·Susanne Arnold, Cordian Beyer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.