Luteinizing hormone receptor in the human corpus luteum: lack of down-regulation during maternal recognition of pregnancy

Human Reproduction
W C DuncanP J Illingworth

Abstract

Luteal progesterone production is dependent on luteinizing hormone (LH) from the pituitary gland. Despite continuing LH secretion, the human corpus luteum undergoes functional luteolysis unless it is 'rescued' by human chorionic gonadotrophin (HCG), produced by the implanting blastocyst. As LH and HCG act through a common receptor, this study sought to determine the expression of the LH/ HCG receptor in the corpus luteum during maternal recognition of pregnancy. Corpora lutea were collected at hysterectomy from women in the normal luteal phase and after luteal 'rescue' with exogenous HCG. In each case the corpus luteum was classified according to the date of the LH surge measured in daily urine samples. The expression of the LH receptor was investigated by Northern blotting, in-situ hybridization and in-situ ligand binding. LH receptor mRNA and ligand binding activity were detected in corpora lutea from all stages of the luteal phase. LH receptor expression and binding were maintained during maternal recognition of pregnancy in the presence of exponentially increasing HCG concentrations. These data show that the LH receptor is maintained throughout the functional life-span of the human corpus luteum and is not down-regulated du...Continue Reading

Citations

Jun 9, 2005·The Journal of Clinical Endocrinology and Metabolism·W Colin DuncanHamish M Fraser
Jan 25, 2019·Panminerva Medica·Carlos DosoutoPeter Humaidan
Oct 17, 2009·International Journal of Clinical Practice·H D Brooks, P J Twomey

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