PMID: 2108884Jan 1, 1990Paper

Luteinizing hormone releasing hormone agonists: the US experience

The Journal of International Medical Research
W Nabors, E D Crawford

Abstract

In a large multicentre trial, 1 mg/day leuprorelin given subcutaneously was as effective as diethylstilboestrol in the treatment of prostatic cancer but with a lower incidence of side-effects, although leuprorelin could induce tumour flare-up. Total androgen ablation using a combination of leuprorelin and the non-steroidal anti-androgen flutamide in the treatment of prostatic cancer was more effective than either orchidectomy or diethylstilboestrol. The efficacy of 1 mg/day leuprorelin given subcutaneously plus 250 mg flutamide three times a day compared with leuprorelin plus placebo was confirmed in a randomized, double-blind study of 603 patients. Progression-free and overall survival were prolonged, and tumour flare-up and other side-effects were reduced in patients with untreated advanced prostatic cancer and in those with minimal disease.

References

Aug 17, 1989·The New England Journal of Medicine·E D CrawfordP J Goodman
Jan 1, 1974·The Journal of Endocrinology·M E HarperK Griffiths
Nov 15, 1984·The New England Journal of Medicine·UNKNOWN Leuprolide Study Group

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Citations

Dec 15, 1993·Cancer·C Mahler

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