PMID: 2114646Jul 1, 1990Paper

Luteinizing hormone-releasing hormone neurons express Fos protein during the proestrous surge of luteinizing hormone

Proceedings of the National Academy of Sciences of the United States of America
W S LeeG E Hoffman

Abstract

The ability of luteinizing hormone-releasing hormone (LHRH) neurons to express the oncogene c-fos was examined during the estrous cycle in rats. The immunocytochemical localization of the c-fos-encoded antigen, Fos, was coupled with the immunocytochemical localization of LHRH. LHRH neurons showed no Fos immunoreactivity during diestrus-1, diestrus-2, estrus, or the morning of proestrus. However, Fos was expressed in LHRH neurons from 1600 to 2200 hours during proestrus. The timing of onset of Fos expression in LHRH neurons during proestrus suggests a strong correlation with increased LH secretion. Pentobarbital, which blocks the preovulatory LH surge, blocked Fos expression in LHRH neurons, but the LHRH neurons expressed Fos on the following afternoon at the time of the expected delayed LH surge. Not all LHRH neurons expressed Fos during the LHRH surge. Approximately half of the LHRH neurons were activated in the preoptic area and anterior hypothalamus; more anteriorly positioned LHRH neurons did not express Fos, resulting in an overall stimulation of 40% of the LHRH neurons. These data provide direct evidence that stimulation of LHRH neurons during proestrus takes place at the LHRH cell bodies, and identify the specific popula...Continue Reading

References

Apr 1, 1978·The Journal of Endocrinology·H M Fraser, T G Baker
Nov 23, 1987·Neuroscience Letters·M Dragunow, H A Robertson

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Citations

Feb 1, 1995·Cellular and Molecular Neurobiology·J E LevineJ H Urban
May 1, 1996·Behavior Genetics·J M KornhauserJ S Takahashi
Apr 5, 2001·The Journal of Nutritional Biochemistry·A R. Del Angel-MezaC Beas-Zárate
Sep 1, 1997·Nature Medicine·W S LeeE Haber
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M P JunierS R Ojeda
Nov 1, 2009·Integrative and Comparative Biology·Wilbur P WilliamsLance J Kriegsfeld
Jun 1, 1991·Journal of Neuroendocrinology·J G VerbalisY P Loh
Jul 1, 1995·Journal of Neuroendocrinology·S Rivest, N Laflamme
Oct 31, 1994·Annals of the New York Academy of Sciences·S M Sagar
Feb 3, 1999·Annals of the New York Academy of Sciences·J G HohmannR A Steiner
Nov 9, 2007·Annual Review of Physiology·Simina M PopaRobert A Steiner
Mar 13, 2010·International Journal of Endocrinology·Megan M Mahoney
Feb 1, 1996·The Journal of Clinical Investigation·M JainE Haber
Sep 23, 2011·Endocrinology·Vincent Prevot
Mar 20, 2010·Endocrine Reviews·Catherine A Christian, Suzanne M Moenter

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