Luteolin, a flavonoid, as an anticancer agent: A review

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Muhammad ImranMohammad S Mubarak

Abstract

Many food-derived phytochemicals and their derivatives represent a cornucopia of new anti-cancer compounds. Luteolin (3,4,5,7-tetrahydroxy flavone) is a flavonoid found in different plants such as vegetables, medicinal herbs, and fruits. It acts as an anticancer agent against various types of human malignancies such as lung, breast, glioblastoma, prostate, colon, and pancreatic cancers. It also blocks cancer development in vitro and in vivo by inhibition of proliferation of tumor cells, protection from carcinogenic stimuli, and activation of cell cycle arrest, and by inducing apoptosis through different signaling pathways. Luteolin can additionally reverse epithelial-mesenchymal transition (EMT) through a mechanism that involves cytoskeleton shrinkage, induction of the epithelial biomarker E-cadherin expression, and by down-regulation of the mesenchymal biomarkers N-cadherin, snail, and vimentin. Furthermore, luteolin increases levels of intracellular reactive oxygen species (ROS) by activation of lethal endoplasmic reticulum stress response and mitochondrial dysfunction in glioblastoma cells, and by activation of ER stress-associated proteins expressions, including phosphorylation of eIF2α, PERK, CHOP, ATF4, and cleaved-caspas...Continue Reading

References

Oct 2, 2001·Pharmacology & Therapeutics·D F BirtW Wang
Jan 16, 2002·Cancer Letters·Takashi KobayashiTakejiro Kuzumaki
Jun 21, 2005·Biochemical and Biophysical Research Communications·Mano HorinakaToshiyuki Sakai
Feb 1, 2006·Experimental Biology and Medicine·Keith R Martin
Aug 12, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Do Y LimJung H Y Park
Mar 26, 2008·Journal of Dental Research·S-F YangY-S Hsieh
Nov 11, 2008·Current Cancer Drug Targets·Yong LinHan-Ming Shen
Jun 11, 2009·Molecular Cancer Therapeutics·Qiong ZhouJing Fang
Dec 17, 2009·Investigational New Drugs·Pandurangan Ashokkumar, Ganapasam Sudhandiran
Apr 21, 2010·Archives of Biochemistry and Biophysics·Hanno BotheThomas Haarmann-Stemmann
May 14, 2010·The Journal of Investigative Dermatology·Lien VerschootenMarjan Garmyn
Jun 19, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Barry M MarkaverichMary Rodriguez
Sep 8, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kyung Pyo KangWon Kim
Jul 23, 2011·International Journal of Cancer. Journal International Du Cancer·Ke-Hung TsuiHorng-Heng Juang
Sep 3, 2011·Future Medicinal Chemistry·Rana Montaser, Hendrik Luesch
Jul 18, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Li-Meng WangMing-Jie Xie
Jul 18, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Ashok Kumar PanduranganSudhandiran Ganapasam
Jul 31, 2012·Journal of Agricultural and Food Chemistry·Dan-feng LuGuo-lin Zhang
Aug 29, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Eun-Ju LeeMi-Kyung Sung
Apr 5, 2013·Journal of Cellular and Molecular Medicine·Sung H LimHyong J Lee
Apr 30, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Vazhapilly Cijo GeorgeRangasamy Ashok Kumar
Jul 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jodee L Johnson, Elvira Gonzalez de Mejia
Nov 30, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shixiong DingJinhua Dai
Jan 31, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Hui ZhangXinyong Luan
Feb 15, 2014·Chemico-biological Interactions·Mon-Yuan YangTsui-Hwa Tseng
Feb 18, 2014·Human & Experimental Toxicology·A K PanduranganS Ganapasam
Mar 20, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Thamaraiselvan RengarajanMaruthaiveeran Periyasamy Balasubramanian

❮ Previous
Next ❯

Citations

May 22, 2019·Antioxidants·Carmen Rodríguez-GarcíaJosé J Gaforio
Nov 14, 2019·Current Drug Delivery·Milad AshrafizadehSaeed Samarghandian
Dec 12, 2019·Phytotherapy Research : PTR·Pratik ShriwasYulin Ren
Dec 13, 2019·Phytotherapy Research : PTR·Milad AshrafizadehSaeed Samarghandian
Apr 17, 2020·Current Topics in Medicinal Chemistry·Gagandeep MaanAwanish Mishra
Jun 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Stefania SutStefano Dall'Acqua
May 19, 2019·International Journal of Molecular Sciences·Hee-Sung ChaeHyungshin Yim
Apr 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vera L M SilvaArtur M S Silva
Jan 24, 2020·Nutrients·Koji Naruishi
Sep 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Javad Mottaghipisheh, Marcello Iriti
Sep 18, 2020·Antioxidants·Shamee Bhattacharjee, Roderick H Dashwood
Sep 6, 2020·Biomolecules·Malgorzata DobrzynskaEwa Florek
Apr 4, 2020·The Journal of International Medical Research·Cui XiongTingting Chi
Apr 9, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Iva PotočnjakRobert Domitrović
Jan 29, 2021·BioFactors·Laura FranzaFranco Pandolfi
Aug 14, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Iva VukelićRobert Domitrović
Nov 28, 2020·Journal of the Science of Food and Agriculture·Lu WangXiuhua Zhao
Dec 29, 2020·BioFactors·Fabian GendrischUte Wölfle
Dec 10, 2020·Cancer Cell International·Milad AshrafizadehSaeed Samarghandian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.