Luteolin protects against lead acetate-induced nephrotoxicity through antioxidant, anti-inflammatory, anti-apoptotic, and Nrf2/HO-1 signaling pathways

Molecular Biology Reports
Alaa Jameel A AlbarakatiAhmed E Abdel Moneim

Abstract

Lead (Pb) is one of the most common heavy metal pollutants affecting living organisms. It induces nephrotoxicity with significant alterations in renal structure and function. Luteolin (LUT) a flavonoid present in various plant products is well known for exhibiting numerous pharmacological properties. We evaluated the protective efficacy of LUT against Pb-induced renal injury in male Wistar rats. Four experimental groups: control, LUT (50 mg/kg, orally), PbAc (20 mg/kg, i.p.), LUT + PbAc (at the aforementioned doses) were maintained for 7 days. PbAc administration significantly increased renal Pb accumulation, urea, and creatinine levels in serum, and induced renal histological alterations. Additionally, compared to the control rats, PbAc-treated rats exhibited significantly low levels of antioxidant enzyme activity and expression (SOD, CAT, GPx and GR), as well as high MDA levels. Moreover, PbAc exposure downregulated Nfe212 and Homx1 mRNA expression and significantly increased inflammatory marker (TNF-α, IL-1β and NO) levels in renal tissue. PbAc significantly upregulated the synthesis of apoptotic related proteins and downregulated antiapoptotic protein expression. Notably, LUT pretreatment of PbAc-treated rats provided signi...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1985·Methods in Enzymology·I Carlberg, B Mannervik
Jan 1, 1984·Methods in Enzymology·H Aebi
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Oct 22, 2008·Planta medica·Günter SeelingerChristoph M Schempp
Jan 20, 2009·Mini Reviews in Medicinal Chemistry·Miguel López-Lázaro
Feb 3, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Robert DomitrovićBiserka Radosević-Stasić
Oct 7, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·K Narayana, Maie Al-Bader
Aug 19, 2010·International Journal of Environmental Research and Public Health·Swaran J S Flora, Vidhu Pachauri
Sep 8, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kyung Pyo KangWon Kim
May 18, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Guo Guang WangCui Zhang
Jul 27, 2011·Environmental Toxicology and Pharmacology·Chan-Min LiuYun-Zhi Sun
Aug 30, 2011·Journal of Hazardous Materials·Ahmed E Abdel MoneimSaleh Al-Quraishy
Apr 11, 2012·International Journal of Molecular Sciences·Marijke JozefczakAnn Cuypers
Jan 8, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Saikat DewanjeeMoumita Gangopadhyay
Mar 8, 2013·Environmental Toxicology and Pharmacology·B V S LakshmiM Aparna
Jun 19, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yao-Chun ZhangEng-Hui Chew
May 8, 2015·Biological Trace Element Research·Ashraf M Abdel-MoneimIsmail A Sadek
Jan 6, 2016·Environmental Toxicology and Pharmacology·Fatma Gökçe ApaydınYusuf Kalender
Mar 12, 2016·Environmental Science and Pollution Research International·Xiangyang WuLiuqing Yang
Mar 15, 2016·Environmental Science and Pollution Research International·Aymen MabroukHassen Ben Cheikh
Oct 18, 2016·Journal of Ginseng Research·Kwang-Soo BaekJae Youl Cho
Oct 22, 2016·Renal Failure·Birsen Yigit ArslanSerdar Altınay
Dec 29, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Shao-Bin XinLi Shen
Jan 27, 2017·Neural Regeneration Research·Saleh Al-QuraishyAhmed E Abdel Moneim
Jan 24, 2018·Mediators of Inflammation·Xin HongZhong Liu
Jun 22, 2018·International Journal of Molecular Sciences·Emilia MetrykaIrena Baranowska-Bosiacka
Jun 23, 2018·Ecotoxicology and Environmental Safety·Ruiqi BaiyunZhigang Zhang
Oct 6, 2018·Journal of Biochemical and Molecular Toxicology·Aymen Mabrouk
Feb 21, 2019·Journal of Cellular Physiology·Masoud Soheili, Mahmoud Salami
May 16, 2019·Molecular Biology Reports·Sanaz Moradi KalbolandiEsrafil Mansouri

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Citations

Aug 23, 2020·Environmental Science and Pollution Research International·Xiao WangYongzhan Bao
Sep 15, 2020·Biological Trace Element Research·Duanya LiuChunhong Wang
Oct 17, 2020·Mediators of Inflammation·Li JiaAhmed E Abdel Moneim
May 1, 2021·Antioxidants·Aleksandra BuhaLuciano Saso

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Methods Mentioned

BETA
PCR
ELISA
MDA

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