Luteolin reduces cancer‑induced skeletal and cardiac muscle atrophy in a Lewis lung cancer mouse model

Oncology Reports
Tiejun ChenYan Jiang

Abstract

Luteolin was recently demonstrated to suppress tumor growth by interfering with nuclear factor (NF)‑κB activation. As the NF‑κB pathway plays a critical role in muscular atrophy associated with cancer cachexia, we aimed to investigate the potential of luteolin to alleviate cancer‑associated cachexia in a Lewis lung cancer mouse model. C57BL/6 mice were divided into three groups: A control group, a model group and a luteolin group. Mice in the model and luteolin groups received a subcutaneous injection of Lewis lung cancer cells, while the control group received PBS. Subsequently, the tumor mass, serum, gastrocnemius muscle and heart were collected on day 21. The serum, gastrocnemius muscle and heart were weighed and prepared for use in enzyme‑linked immunosorbent assay (ELISA), western blotting (WB) and quantitative reverse transcription polymerase chain reaction (qRT‑PCR) analyses. The results revealed that the tumor‑free body mass was significantly reduced in tumor‑bearing mice compared with that of mice in the other groups. The gastrocnemius muscle mass and heart mass were greater in the luteolin treatment group than in the control group. Tumor necrosis factor (TNF)‑α and interleukin (IL)‑6 levels were lower in the luteolin ...Continue Reading

Citations

Mar 11, 2020·Cancer Metastasis Reviews·Simonetta AusoniGiuseppe Azzarello
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Takeshi NikawaIori Sakakibara
Aug 28, 2021·International Journal of Molecular Sciences·Ibrahim Y AbdelgawadBeshay N Zordoky

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