LUTS in pelvic ischemia: a new concept in voiding dysfunction

American Journal of Physiology. Renal Physiology
Portia ThurmondK M Azadzoi

Abstract

Lower urinary tract symptoms (LUTS) are a group of voiding symptoms affecting both genders as they age. Traditionally, LUTS in men were commonly attributed to bladder outlet obstruction (BOO) due to benign prostatic enlargement (BPE). It was later shown that, in approximately one-third to more than one-half of cases, LUTS in men are not associated with BOO. Urodynamic changes in the male bladder and symptom scores in aging men were found to be identical to their age-matched female counterparts. These observations suggested that LUTS in the elderly do not necessarily relate to BOO and may result from local changes in bladder muscle, nerves, and blood vessels. However, aging factors predisposing to bladder dysfunction and LUTS remain unknown. Growing evidence suggests that aging-associated pelvic ischemia may be a primary factor in the development of nonobstructed nonneurogenic overactive bladder and LUTS. First identified in experimental models and later in clinical studies, pelvic ischemia has been shown to compromise the lower urinary tract structure and lead to dysfunction. Structural and functional consequences of bladder and prostate ischemia have been documented in animal models. Clinical studies have shown that bladder an...Continue Reading

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Citations

Dec 15, 2016·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Simon Allen, Ivan Aghajanyan
Jul 1, 2016·American Journal of Physiology. Renal Physiology·Vittore VerrattiAnna Maria Aloisi
May 19, 2017·American Journal of Physiology. Renal Physiology·Katerina OkekeMartin C Michel
Feb 10, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Martin C Michel
Aug 14, 2020·Lower Urinary Tract Symptoms·Hande O Altunkaynak-Camca, Nuray Yazihan
Sep 29, 2020·Research and Reports in Urology·Jing-Hua YangKazem Azadzoi
Aug 19, 2020·International Urology and Nephrology·Thomas F MonaghanJason M Lazar
Feb 5, 2021·Sexual Medicine·Yohei MatsudaNaoya Masumori
May 11, 2021·Taiwanese Journal of Obstetrics & Gynecology·Hui-Hsuan LauWen-Chu Huang
Aug 14, 2021·Investigative and Clinical Urology·Jing-Hua YangKazem M Azadzoi

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