LV Dyssynchrony Assessed With Phase Analysis on Gated Myocardial Perfusion SPECT Can Predict Response to CRT in Patients With End-Stage Heart Failure

Research in Cardiovascular Medicine
Nasrin AzizianMajid Haghjoo

Abstract

Cardiac resynchronization therapy (CRT) is an established treatment in patients with end-stage heart failure and wide QRS complex. However, about 30% of patients do not benefit from CRT (non-responder). Recent studies with tissue Doppler imaging yielded disappointing results in predicting CRT responders. Phase analysis was developed to allow assessment of LV dyssynchrony by gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (GMPS). The aim of present study was to investigate the role of quantitative GMPS-derived LV dyssynchrony data to predict CRT responder. Thirty eligible patients for CRT implantation underwent GMPS and echocardiography. Response to CRT was evaluated six months after the device implantation. Clinical response to CRT was defined as 50 meters increase in 6-minute walking test (6-MWT) distance. Echocardiographic response to CRT was defined as ≥ 15% decrease in left ventricular end-systolic volume (LVESV). The lead position was considered concordant if it was positioned at the area of latest mechanical activation, and discordant if located outside the area of latest mechanical activation. Clinical response to CRT was observed in 74% of patients. However, only 57% of patients wer...Continue Reading

References

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Citations

Nov 23, 2015·Cardiology Clinics·Hussein Abu DayaPrem Soman
Apr 1, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Weihua Zhou, Guang-Uei Hung
Feb 10, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Saara SillanmäkiTomi Laitinen
Sep 10, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Aviral Vij, Saurabh Malhotra
May 31, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Marat FudimSalvator Borges-Neto

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Software Mentioned

Quantitative Gated SPECT ( QGS )
QGS
Quantitative SPECT - QGS
GMPS

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