LV Mass as a Predictor of CVD Events in Older Adults With and Without Metabolic Syndrome and Diabetes

JACC. Cardiovascular Imaging
Khiet HoangNathan D Wong

Abstract

The purpose of this study was to examine the prognostic significance of left ventricular (LV) mass for cardiovascular disease (CVD) events in older adults with and without metabolic syndrome (MetS) and diabetes mellitus (DM). MetS and DM are associated with increased CVD risk, but it is unclear in these groups whether subclinical CVD as shown by increased LV mass improves risk prediction compared to standard risk factors in older individuals. We studied 3,724 adults (mean 72.4 ± 5.4 years of age, 61.0% female, 4.4% African-American) from the Cardiovascular Health Study who had MetS but not DM or had DM alone or had neither condition. Cox regression was used to examine the association of LV mass, (alone and indexed by height and body surface area [BSA]) as determined by echocardiography, with CVD events, including coronary heart disease (CHD), stroke, heart failure (HF), and CVD death, as well as total mortality. We also assessed the added prediction, discriminative value, and net reclassification improvement (NRI) for clinical utility of LV mass compared to standard risk factors. Over a mean follow-up of 14.2 ± 6.3 years, 2,180 subjects experienced CVD events, including 986 CVD deaths. After adjustment for age, sex and standard...Continue Reading

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Citations

Sep 19, 2015·JACC. Cardiovascular Imaging·Sheldon E Litwin
Dec 3, 2016·Journal of Hypertension·Alessandro MalobertiCristina Giannattasio
Jun 27, 2017·Journal of Hypertension·Cesare CuspidiGiuseppe Mancia
Apr 14, 2019·BMC Medical Imaging·Alexandra G GheorgheJytte Banner
Oct 27, 2020·Journal of Occupational and Environmental Medicine·Brittany S HollerbachDenise L Smith
Nov 3, 2020·Journal of Cardiovascular Medicine·Georgios GeorgiopoulosPier-Giorgio Masci

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