LVAD Pump Flow Does Not Adequately Increase With Exercise.

Artificial Organs
Christoph GrossFrancesco Moscato

Abstract

Left ventricular assist devices (LVADs) restore cardiovascular circulatory demand at rest with a spontaneous increase in pump flow to exercise. The relevant contribution of cardiac output provided by the LVAD and ejected through the aortic valve for exercises of different intensities has been barely investigated in patients. The hypothesis of this study was that different responses in continuous recorded pump parameters occur for maximal and submaximal intensity exercises and that the pump flow change has an impact on the oxygen uptake at peak exercise (pVO2 ). Cardiac and pump parameters such as LVAD flow rate (QLVAD ), heart rate (HR), and aortic valve (AV) opening were analyzed from continuously recorded LVAD data during physical exercises of maximal (bicycle ergometer test) and submaximal intensities (6-min walk test and regular trainings). During all exercise sessions, the LVAD speed was kept constant. Cardiac and pump parameter responses of 16 patients for maximal and submaximal intensity exercises were similar for QLVAD : +0.89 ± 0.52 versus +0.59 ± 0.38 L/min (P = 0.07) and different for HR: +20.4 ± 15.4 versus +7.7 ± 5.8 bpm (P < 0.0001) and AV-opening with 71% versus 23% of patients (P < 0.0001). Multi-regression anal...Continue Reading

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Citations

Aug 16, 2019·European Journal of Preventive Cardiology·Marco Masetti, Francesco Grigioni
Jun 7, 2019·The International Journal of Artificial Organs·Dmitry TelyshevSergey Selishchev
Jan 23, 2020·Artificial Organs·Paul S Malchesky
Jan 17, 2020·Artificial Organs·Christoph GrossFrancesco Moscato
Jul 10, 2020·PloS One·Libera FresielloBart Meyns
Oct 24, 2020·Expert Review of Medical Devices·Andrew F StephensRobert F Salamonsen
Mar 7, 2021·Heart Failure Clinics·Concetta Di NoraFrancesco Antonini-Canterin
Aug 25, 2019·The Journal of Thoracic and Cardiovascular Surgery·Marcus GraneggerDaniel Zimpfer
Jun 30, 2021·Current Cardiology Reports·Sara RovaiPiergiuseppe Agostoni
Aug 16, 2021·JACC. Heart Failure·Kiran K MirzaUNKNOWN PRO-VAD Investigators

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Clinical Trials Mentioned

NCT01981642

Software Mentioned

Matlab

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