LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection.

BioRxiv : the Preprint Server for Biology
Bryan E JonesEster Falconer

Abstract

SARS-CoV-2 poses a public health threat for which therapeutic agents are urgently needed. Herein, we report that high-throughput microfluidic screening of antigen-specific B-cells led to the identification of LY-CoV555, a potent anti-spike neutralizing antibody from a convalescent COVID-19 patient. Biochemical, structural, and functional characterization revealed high-affinity binding to the receptor-binding domain, ACE2 binding inhibition, and potent neutralizing activity. In a rhesus macaque challenge model, prophylaxis doses as low as 2.5 mg/kg reduced viral replication in the upper and lower respiratory tract. These data demonstrate that high-throughput screening can lead to the identification of a potent antiviral antibody that protects against SARS-CoV-2 infection. LY-CoV555, an anti-spike antibody derived from a convalescent COVID-19 patient, potently neutralizes SARS-CoV-2 and protects the upper and lower airways of non-human primates against SARS-CoV-2 infection.

Citations

Jan 22, 2021·JAMA : the Journal of the American Medical Association·Robert L GottliebDaniel M Skovronsky
Apr 14, 2021·Expert Review of Vaccines·Lianlian BianZhenglun Liang
Apr 24, 2021·Microbial Cell Factories·Norma A Valdez-CruzMauricio A Trujillo-Roldán
Mar 9, 2021·Nature·Pengfei WangDavid D Ho
Apr 25, 2021·Cell Research·Haolin LiuGongyi Zhang
Apr 27, 2021·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Deepak KumarNagendra R Hegde
Apr 30, 2021·Antibody Therapeutics·Yaping Sun, Mitchell Ho
May 1, 2021·Viruses·Aeron C Hurt, Adam K Wheatley
Jun 3, 2021·Pharmaceuticals·Bauso Luana VittoriaAlessandra Bitto
May 31, 2021·Frontiers in Molecular Biosciences·Miao Mei, Xu Tan

Methods Mentioned

BETA
surface plasmon resonance
X-ray

Clinical Trials Mentioned

NCT04411628
NCT04427501
NCT04497987
NCT04501978

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