PMID: 6969779Jan 1, 1981Paper

Lyb-2 system of mouse B cells. Evidence for a role in the generation of antibody-forming cells

The Journal of Experimental Medicine
H YakuraE A Boyse

Abstract

The Lyb-2 cell-surface alloantigens of the mouse are selectively and perhaps exclusively expressed in the B lymphocyte lineage, but not on antibody- forming cells. Thus if the Lyb-2 molecule is concerned in specific B cell function, it must participate in the generative phase of the antibody response. Accordingly, monoclonal Lyb-2 antibody was found to depress the plaque- forming cell (PFC) response to sheep erythrocytes in 5-d Mishell-Dutton assays when added within the first 3 d of culture, but not later. The rate of PFC generation was not affected, signifying an absolute reduction in the number of PFC generated. Because reduction of PFC counts by Lyb-2 antibody was not affected by exclusion of Lyt-2(+) T cells, it is unlikely that the reduction depends on augmented suppression by T cells. Augmented B cell- mediated suppression is also unlikely, because the PFC response of serial combinations of congenic Lyb-2.1 and Lyb-2.2 cells, in the presence of monoclonal Lyb-2.1 antibody, was reduced only in direct proportion to the number of Lyb-2.1 cells present. The PFC response of Lyb-2.1/Lyb-2.2 heterozygous cells was not reduced by Lyb-2.1 antibody, presumably because generation of PFC is impeded only if most Lyb-2 sites are block...Continue Reading

References

Jan 1, 1977·Immunological Reviews·D E MosierW E Paul
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Sep 1, 1967·The Journal of Experimental Medicine·R I Mishell, R W Dutton

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Citations

Jan 1, 1988·Immunogenetics·T AshidaM Katagiri
Dec 11, 2008·Journal of Clinical Immunology·Hsin-Jung Wu, Subbarao Bondada
Sep 1, 1994·Immunology Today·J Gordon
Apr 12, 2002·Veterinary Immunology and Immunopathology·Aric N RogersCynthia L Baldwin
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E NakayamaJ R Parnes
Jan 1, 1997·International Reviews of Immunology·J F KearneyF Shu
Nov 1, 1992·American Journal of Hematology·R SchwartingB Dörken
May 4, 1992·Annals of the New York Academy of Sciences·H Van de VeldeK Thielemans
Aug 24, 2010·Immunological Reviews·Yuval YarkoniJohn C Cambier
Jan 1, 1983·Immunology Today·I F McKenzie, H Zola
Jan 1, 1982·Immunological Reviews·F W ShenJ S Tung
Sep 1, 1982·European Journal of Immunology·A Chayen, R M Parkhouse
Sep 1, 1982·European Journal of Immunology·S Marshall-ClarkeR M Parkhouse
Jan 1, 1982·Immunological Reviews·B Subbarao, D E Mosier
Oct 18, 2014·Frontiers in Immunology·Edward A Clark
Jun 1, 1991·European Journal of Immunology·M KamalJ Gordon
Jun 1, 1991·European Journal of Immunology·I Von HoegenJ R Parnes
Jun 20, 1991·Nature·A L DeFranco
Jun 20, 1991·Nature·H Van de VeldeK Thielemans

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