PMID: 6984010Jan 1, 1982Paper

Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody

Immunogenetics
F W SymingtonJ Sprent

Abstract

A DBA/1 B10.D2-specific monoclonal antibody (CY34) is described which defines a new murine B lymphocyte differentiation antigen designated Lyb-8.2. The ontogeny, strain distribution, and cell-surface density of the antigen were studied by radioimmunoassay and by fluorescence-activated cell sorter (FACS) analysis. Lyb-8.2 appears to be expressed on pre-B cells and on all mature B lymphocytes. Lyb-8.2 molecules immunoprecipitated from surface labeled B10.D2 spleen cells migrated in polyacrylamide gels with an apparent mol. wt. of 95,000-105,000 daltons and were bound by lentil lectin. The expression of Lyb-8.2 is controlled by a locus on chromosome 7 that is closely linked to Gpi-1 and RP-2. Added Lyb-8.2-specific antibody did not measurably impair B lymphocyte function in several in vitro systems studied.

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Citations

Jan 1, 1987·Immunogenetics·H C MorseU Hämmerling
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·E M RinchikJ Peters
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Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karen M HaasThomas F Tedder
Nov 1, 1996·Science·T L O'KeefeM S Neuberger

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