Lycopene: Hepatoprotective and Antioxidant Effects toward Bisphenol A-Induced Toxicity in Female Wistar Rats

Oxidative Medicine and Cellular Longevity
Haidy G Abdel-RahmanAaser M Abdelazim

Abstract

Bisphenol A (BPA)-an endocrine disruptor xenoestrogen-is widely spread in the environment. Lycopene (LYC) is an antioxidant phytochemical carotenoid. The hereby study was designed to verify the deleterious effect of BPA on cyclic female rats' hepatic tissue as well as evaluation of the effect of LYC toward BPA hepatic perturbation. Twenty-eight female Wistar rats were allocated equally into four groups: control group, LYC group (10 mg/kg B.wt), BPA group (10 mg/kg B.wt), and BPA + LYC group (the same doses as former groups). The treatments were given daily via gavage to the rats for 30 days. The rats in BPA displayed high activities of serum liver enzymes with low levels of total proteins (TP) and albumin. Moreover, BPA induced hepatic oxidative stress via depletion of antioxidant enzymes concomitant with augmentation of lipid peroxidation, increased comet tail DNA %, and overexpression of caspase-3. Meanwhile, LYC administration reduced the cytotoxic effects of BPA on hepatic tissue, through improving the liver function biomarkers and oxidant-antioxidant state as well as DNA damage around the control values. These findings were confirmed by hepatic histopathological examination. Finally, LYC credited to have a noticeable prote...Continue Reading

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Citations

Jan 10, 2020·Environmental Science and Pollution Research International·Rania Abdelrahman ElgawishHeba M A Abdelrazek
Jul 1, 2020·International Journal of Molecular Sciences·Ekaterina ProshkinaAlexey Moskalev
Aug 29, 2020·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Mehmet KirisciUlku Kazanci
Sep 2, 2020·Environmental Science and Pollution Research International·Zeynep ErdemliSemir Gul
Jun 4, 2020·Environmental Science and Pollution Research International·Chao HanWanyu Shi
Oct 10, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Walaa WadieHelmy Moawad Sayed
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Dec 10, 2019·Journal of Agricultural and Food Chemistry·Yi ZhaoJin-Long Li

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