Lycopene supplementation (passata sauce) reduces apoptosis but does not affect oxidant-responsive heme oxygenase-1 in human lymphocytes

Nutrition
Daniella MarkovitchDylan Thompson

Abstract

We tested the hypothesis that lycopene supplementation reduces the expression of oxidant-responsive heme oxygenase-1 (HO-1) in basal conditions and in response to an oxidant challenge and determined whether this is temporally associated with increased cell viability. We determined basal and stimulated ex vivo expression of HO-1 and cell viability in lymphocytes from volunteers after lycopene supplementation. Twenty-four healthy young men on a low lycopene diet consumed 1) 170 g of passata sauce with butter or 2) butter alone for 3 wk in a randomized crossover design. Plasma lycopene concentrations at the end of the tomato and control trials were 0.54 +/- 0.20 versus 0.20 +/- 0.15 micromol/L, respectively (P < 0.05). There was a significant increase in the proportion of live cells (91 +/- 5% versus 87 +/- 9%) and a corresponding reduction in apoptosis (6 +/- 4% versus 11 +/- 9%) in untreated lymphocytes after supplementation (P < 0.05), with no effect on cell viability in response to hydrogen peroxide treatment. HO-1 protein expression in basal conditions and induction of HO-1 after hydrogen peroxide treatment was not different between trials. Lycopene supplementation did not affect basal oxidative stress or susceptibility to ox...Continue Reading

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Citations

Mar 13, 2010·Antioxidants & Redox Signaling·Iris F F Benzie, Sissi Wachtel-Galor
Nov 15, 2011·Menopause : the Journal of the North American Menopause Society·Rachel S CasasMolly B Conroy
Feb 6, 2013·Biochemistry. Biokhimii︠a︡·N K ZenkovV O Tkachev
Aug 8, 2014·Obstetrical & Gynecological Survey·Galit Levi DunietzLouise Margaret O'Brien

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