PMID: 109097May 1, 1979

Lyme arthritis: correlation of serum and cryoglobulin IgM with activity, and serum IgG with remission

Arthritis and Rheumatism
A C SteereS E Malawista

Abstract

Forty-eight patients with erythema chronicum migrans (ECM) were studied prospectively for 6 to 18 months. Twenty-six patients had no later symptoms, but 22 subsequently developed Lyme arthritis and 9 of them also experienced neurologic abnormalities. Eighty-seven percent of patients with active ECM followed by subsequent involvement had cryoglobulins containing IgM compared to only 13% of those with active ECM and no later symptoms. The former group also had significantly lower IgG, C3 and C4 levels. Sixty-seven percent of patients still had serum cryoglobulins when neurologic disease was most active, and 45% had them when joint symptoms were most severe, but only 11% continued to have small amounts in remission. The number of patients who continued to have serum cryoglobulins with recurrent attacks of arthritis decreased with time. In contrast, patients always had cryoglobulins in joint fluid, a finding Lyme arthritis shares with rheumatoid arthritis. The cryoprecipitates from 2 of 10 patients contained particles with internal structure, but their viral nature is problematic. All components of antisera obtained from goats and rabbits immunized with cryoglobulins were absorbed by normal human sera. The amount of IgM in cryoglob...Continue Reading

References

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Citations

Mar 26, 2004·Nature Reviews. Immunology·A C Steere, Lisa Glickstein
Mar 31, 1983·The New England Journal of Medicine·A C SteereS E Malawista
Sep 1, 1983·The Western Journal of Medicine·J CampagnaD P Furman
Jul 1, 1985·Pediatric Dermatology·S Hurwitz
Nov 3, 1998·Annals of the Rheumatic Diseases·P CacoubJ C Piette
Jan 1, 1997·Annual Review of Immunology·L H Sigal
Aug 1, 1983·The Journal of Clinical Investigation·A G BarbourA C Steere
Jan 1, 1988·Scandinavian Journal of Rheumatology. Supplement·K M GoebelF Neurath
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Jan 1, 1988·Annals of the New York Academy of Sciences·A C Steere
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May 13, 2006·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Farid E Ahmed
Aug 31, 1989·The New England Journal of Medicine·A C Steere
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Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Srimoyee GhoshBrigitte T Huber
Jan 1, 1989·Rheumatology International·S E Malawista

Related Concepts

Arthritis, Viral
Centrifugation, Density Gradient
Complement C3 precursor
Complement C4, Precursor
Cryoproteins
Immunodiffusion Measurement
Goat
Polyglobin
IgM2
Immunoelectrophoresis

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