Abstract
Ninety-nine patients who were referred to a clinic for infectious diseases on suspicion of Lyme borreliosis and whose major symptoms were fatigue, headache, myalgia and arthralgia were studied retrospectively to find out if there was any difference in symptomatology between patients who were seropositive or seronegative to Borrelia burgdorferi. 64/82 (78%) patients remembered one or more tick bites during previous years and 32/74 (43%) patients had a history of erythema migrans. Fatigue, headache, myalgia and arthralgia occurred in 84%, 72%, 54%, and 63% of the patients, respectively. 62/99 (63%) patients had an elevated IgM and/or IgG antibody titer to B. burgdorferi. There was no difference in frequency of symptoms between seropositive and seronegative individuals. 48/99 (49%) patients were treated with antibiotics, mostly oral doxycycline. Only 50% were improved after treatment. On follow-up 2 to 4 years after the first visit, 40% of the patients had recovered completely, 31% were improved, 24% reported unaltered symptoms and four patients were impaired. There was no difference in symptoms on follow-up between seropositive or seronegative patients. It is concluded that there probably is an overdiagnosis of Lyme borreliosis a...Continue Reading
References
Nov 11, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H M FederR W Ryan
Dec 1, 1992·Journal of Clinical Microbiology·I SchwartzC S Pavia
Mar 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H R BruckbauerB Wilske
Jul 1, 1992·Journal of Clinical Microbiology·A M Lebech, K Hansen
Mar 1, 1990·Journal of Clinical Microbiology·M KarlssonG Stiernstedt
Jan 1, 1990·Scandinavian Journal of Infectious Diseases·R GustafsonM Forsgren
Aug 31, 1989·The New England Journal of Medicine·A C Steere
Jul 1, 1987·The Journal of Infectious Diseases·L A MagnarelliR C Johnson
Jun 1, 1986·Annals of Internal Medicine·D R SnydmanK M Pariser
May 1, 1985·Journal of Clinical Microbiology·G T StiernstedtB Sköldenberg
Apr 24, 1995·The American Journal of Medicine·L A Magnarelli
Apr 24, 1995·The American Journal of Medicine·L H Sigal
Apr 23, 1994·Lancet·H W PfisterK Weber
May 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M K NohlmansC P van Boven
Jun 1, 1994·Journal of Clinical Microbiology·S Hammers-BerggrenG Stiernstedt
Oct 15, 1994·Annals of Internal Medicine·N A ShadickM H Liang
Jan 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P K CoyleK Amin
Apr 1, 1994·The American Journal of Medicine·L H Sigal
Jan 27, 1994·The New England Journal of Medicine·J J NoctonA C Steere
Sep 15, 1993·Annals of Internal Medicine·R W LightfootR L Kaufman
Mar 1, 1993·Infection·F StrleM Jereb
Jan 1, 1993·Neurology·S Hammers-BerggrenM Karlsson
Apr 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D R Burdge, D P O'Hanlon
Jan 1, 1996·Infection·K Weber
Jan 1, 1996·Infection·R MuelleggerM Volkenandt
Jan 1, 1996·Infection·W Graninger
Citations
Jul 3, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M F SeidelH Vetter
Oct 22, 2013·Ticks and Tick-borne Diseases·Petr Zeman, Cestmir Benes
Feb 24, 2001·Cellular Microbiology·M de GradoB B Finlay
Jul 10, 2002·Cellular Microbiology·Sandra L MarcusB Brett Finlay
Oct 13, 2006·Current Opinion in Infectious Diseases·J Berglund
Jul 31, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·U LjøstadA Mygland
Jan 4, 2001·Clinical and Diagnostic Laboratory Immunology·G A KouzmitchevaG P Smith
Jul 20, 2012·Journal of the American Medical Informatics Association : JAMIA·Stephen G JonesWilliam Conner
Sep 16, 2008·Infection·R BennetB Zweygberg Wirgart
Aug 6, 2002·Scandinavian Journal of Infectious Diseases·Johan BerglundHallstein Walter
Dec 8, 2015·Advances in Medical Sciences·Piotr CzuprynaJoanna Zajkowska
Jul 4, 2012·Spatial and Spatio-temporal Epidemiology·Stephen G JonesAnand Jayakaran
Nov 21, 2007·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Hubert WanyuraDanuta Samolczyk-Wanyura
Feb 25, 2006·Chemotherapy·Raphael B StrickerJoseph J Burrascano
Dec 8, 2005·CNS Drugs·Göran Günther, Mats Haglund