Lyme carditis in immunodeficient mice during experimental infection of Borrelia burgdorferi

Virchows Archiv. A, Pathological Anatomy and Histopathology
G ZimmerM M Simon

Abstract

Recently, we described the severe combined immunodeficiency (scid) mouse as a laboratory model for B. burgdorferi infection. Scid mice inoculated with the virulent low-passage tick isolate Borrelia burgdorferi ZS7 developed a severe pancarditis involving endocardium, myocardium and epicardium in the absence of functional B- or T-cells. Soon after inoculation perivascular infiltration was observed, later diffuse infiltration of the interstitium of the subendocardial and subepicardial areas was seen. The infiltrate was mainly mononuclear and predominantly composed of Mac-1+ cells. Concomitantly, fibroblast proliferation and augmented collagen deposition occurred in the interstitium. This was associated with the presence of B. burgdorferi organisms. The histopathological and ultrastructural findings observed in scid mice resemble those observed in human Lyme carditis. The data emphasize the suitability of the scid mouse as a model in which to study the role of the immune system in the pathogenesis of Lyme carditis.

References

May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·U E SchaibleM M Simon
Jan 1, 1988·Annals of the New York Academy of Sciences·B WilskeM Kramer
Aug 31, 1989·The New England Journal of Medicine·A C Steere
Jul 1, 1989·The Journal of Infectious Diseases·J de KoningH J Crijns
Jan 1, 1988·Annals of the New York Academy of Sciences·D SteinmullerS J Galli
Dec 1, 1988·The New England Journal of Medicine·R J DattwylerM G Golightly
Dec 1, 1986·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·A C SteereS E Malawista
Dec 1, 1986·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·P H Duray, A C Steere
Apr 1, 1987·The Journal of Infectious Diseases·J L Coleman, J L Benach
Feb 10, 1983·Nature·G C BosmaM J Bosma
Mar 31, 1983·The New England Journal of Medicine·A C SteereS E Malawista
Jul 1, 1980·Annals of Internal Medicine·A C SteereS E Malawista

❮ Previous
Next ❯

Citations

Dec 14, 1999·The Journal of Laboratory and Clinical Medicine·J L Coleman, J L Benach
Aug 6, 2002·Medical Hypotheses·D J GrabH-N Lanners
Jun 1, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Charles R BrownChristie M Loiacono
Jan 1, 1994·Microbiology and Immunology·T MasuzawaY Yanagihara
Jul 25, 2006·Infection and Immunity·Stephen W BartholdSunlian Feng
Nov 15, 2006·Infection and Immunity·Ruth R MontgomeryCharles R Brown
May 2, 2003·Microbiology·Jennifer C Miller, Brian Stevenson
May 8, 2020·Trends in Cardiovascular Medicine·Cynthia YeungAdrian Baranchuk
May 14, 2021·Microbiology and Molecular Biology Reviews : MMBR·James L ColemanA Wali Karzai
Sep 1, 1995·Infection and Immunity·B P GuoM Höök

❮ Previous
Next ❯