Abstract
In the United States, Lyme disease is the most common arthropod-borne infection. The majority of cases are reported from the Northeast, the Midwest, and California, which are areas with established foci of Borrelia burgdorferi. Advances in the understanding of the epidemiology of Ixodes ticks, the established vector for transmission of Lyme disease, provided strategies to reduce tick populations and the risk of acquiring disease. Genotypic diversity of subspecies of B. burgdorferi has been associated with differences in disease expression. New methods for detection of B. burgdorferi have expanded understanding of the pathogenesis of Lyme disease and provided clues into the mechanisms responsible for persistent symptoms. A safe vaccine for the prevention of Lyme disease in humans has been developed, and clinical vaccine efficacy trials are currently under way.
Citations
Aug 26, 1998·Lancet·R B Nadelman, G P Wormser
Aug 30, 2000·Clinical Therapeutics·R T SchoenD L Parenti
Mar 15, 2003·Clinical Therapeutics·Robert T SchoenErol Fikrig
Nov 26, 1998·Clinical Therapeutics·E MaesN Ray
Sep 1, 1996·The Journal of Emergency Medicine·G Sternbach, C L Dibble
May 1, 1997·The Journal of Emergency Medicine·G Sternbach, J Varon
Aug 1, 1996·Current Opinion in Immunology·K P Seiler, J J Weis
Apr 26, 2003·Joint, Bone, Spine : Revue Du Rhumatisme·Géraldine MullerJean Francis Maillefert
May 30, 2001·Current Opinion in Microbiology·R M Wooten, J J Weis
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chris M OlsonJuan Anguita
Sep 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J AnguitaE Fikrig
Aug 1, 1997·Arthritis and Rheumatism·L M PachmanA R Dyer
Oct 11, 2003·FEMS Microbiology Reviews·Juan AnguitaErol Fikrig