Lyme neuroborreliosis in the rhesus monkey

Seminars in Neurology
J D EnglandM T Philipp

Abstract

Although there are several animal models of Lyme disease, only the rhesus monkey model exhibits all of the key manifestations of the disease. After infection with Borrelia burgdorferi, rhesus monkeys develop signs of early localized, early disseminated, and chronic Lyme disease. Specific features include erythema migrans, uveitis, myocarditis, arthritis, and disease of the peripheral and central nervous system. One of the unique features of the rhesus monkey model is the development of Lyme neuroborreliosis. Peripheral nervous system (PNS) involvement is usually in the form of a mononeuropathy multiplex with primarily axonal-loss features. Evidence of central nervous system (CNS) disease has included CSF pleocytosis, meningeal inflammation, spinal cord lesions, and polymerase chain reaction (PCR) data consistent with chronic CNS infection. The pathogenesis of Lyme neuroborreliosis is not well understood, but it is likely to involve complex interactions between B. burgdorferi and host immune mechanisms.

Citations

Jun 14, 2003·Vector Borne and Zoonotic Diseases·Guiqing Wang
Aug 13, 2008·Infection and Immunity·Andrea L F BernardinoMario T Philipp
Jan 25, 2005·Infection and Immunity·Dennis J GrabKwang Sik Kim
Sep 19, 2008·Journal of Neuropathology and Experimental Neurology·Diana LondoñoDiego Cadavid
Mar 7, 1998·Neurologic Clinics·P J WynneA J Silver
Oct 3, 2018·Continuum : Lifelong Learning in Neurology·John J Halperin
Jun 27, 1998·Current Opinion in Neurology·A Haass
Dec 29, 2020·Ticks and Tick-borne Diseases·Derick ThompsonCatherine A Brissette
Feb 3, 2020·Trends in Parasitology·Quentin BernardNathalie Boulanger
Jun 27, 2003·Biochemical Pharmacology·Hong JinMary Struthers

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