journal cover

Lymph node biopsy analysis reveals an altered immunoregulatory balance already during the at-risk phase of autoantibody positive rheumatoid arthritis

European Journal of Immunology

Sep 21, 2016

T H RamwadhdoebeL G M van Baarsen

Abstract

The balance between proinflammatory and regulatory CD4(+) T cells is tightly controlled in lymphoid organs. In autoimmune diseases this balance is altered in the periphery and target tissue of patients. However, not much is known about the balance initiated in lymphoid organs during the...read more

Mentioned in this Paper

Peripheral
Interferon Type II
Interferons
Recombinant Cytokines
Tr1 Cells
Lymph Nodes
Lymphocyte Activation
Interleukin-17A
Relative Risk
T-helper Cell Type 1
2
1
10
Paper Details
References
  • References30
  • Citations5
123

Similar Papers Found In These Feeds

Memory T Cells

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Interferon Signalling

Via interaction with their specific receptors, interferons (IFNs) activate signal transducer and activator of transcription (STAT) complexes. STAT activation initiates the classical Janus kinase-STAT (JAK-STAT) signaling pathway. In this pathway, JAKs associate with IFN receptors and, following receptor engagement with IFN, phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription factor called IRF9—and moves into the cell nucleus. Inside the nucleus, the ISGF3 complex binds to specific nucleotide sequences called IFN-stimulated response elements (ISREs) in the promoters of certain genes, known as IFN stimulated genes. Discover the latest research on interferon signalling here.

Systemic Autoimmunity

Systemic autoimmunity is a complex disease process that results from a loss of immunological tolerance, characterized by the inability of the immune system to discriminate self from non-self. Discover the latest research on Systemic Autoimmunity here.

Follicular T Helper Cells

Follicular t helper cells are an important subset of helper t-cells which help to the formation of germinal centers and b-cells differentiation. Discover the latest research on follicular t helper cells here.

Lymphoid Organ Development

The precise localization and structure of lymphoid organ development allows for an orchestrated immune response to an array of potential pathogens. Discover the latest research on Lymphoid Organ Development here.

Treg Cells

Treg cells are critical for the maintenance of immune homeostasis and suppression of naturally occurring self-reactive t cells. Discover the latest research on treg cells here.

Immune Tolerance

Immune tolerance happens when the immune system is not responsive to a substance or organism and does not elicit an immune response. This is a normal physiological response for some antigens, especially when detecting self from non-self. This has been a potential area of therapy for some disorders. Here is the latest research on immune tolerance.

© 2020 Meta ULC. All rights reserved

Lymph node biopsy analysis reveals an altered immunoregulatory balance already during the at-risk phase of autoantibody positive rheumatoid arthritis

European Journal of Immunology

Sep 21, 2016

T H RamwadhdoebeL G M van Baarsen

PMID: 27645315

DOI: 10.1002/eji.201646393

Abstract

The balance between proinflammatory and regulatory CD4(+) T cells is tightly controlled in lymphoid organs. In autoimmune diseases this balance is altered in the periphery and target tissue of patients. However, not much is known about the balance initiated in lymphoid organs during the...read more

Mentioned in this Paper

Peripheral
Interferon Type II
Interferons
Recombinant Cytokines
Tr1 Cells
Lymph Nodes
Lymphocyte Activation
Interleukin-17A
Relative Risk
T-helper Cell Type 1
2
1
10

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References30
  • Citations5
123
/papers/lymph-node-biopsy-analysis-reveals-an-altered/27645315