Lymph node counts, rates of positive lymph nodes, and patient survival for colon cancer surgery in Ontario, Canada: a population-based study

Journal of Surgical Oncology
Luke BuiMarko Simunovic

Abstract

This study assessed lymph node counts, lymph node status (positive or negative), and survival among patients undergoing colon cancer surgery in Ontario, Canada. We obtained data from the Ontario Cancer Registry on 960 patients who underwent a major colon cancer resection in years 1991-1993. Patients and hospitals were ranked by lymph node count to correlate lymph node counts and lymph node status. For node-negative patients we assessed the influence of patient, hospital, and tumor factors on lymph node counts and survival. The rate of node-positive patients was similar among the lymph node count groups. For example, the odds ratio of a patient being node positive if the lymph node count was 10-36 versus 1-3 was 1.0 (CI 0.6-1.6, P = 0.42). Among node-negative patients, survival was improved for patients with a high (10-36) versus low (1-3) lymph node count (HR 0.6, CI 0.4-1.0, P = 0.03). No patient, hospital, or tumor factors predicted both a higher lymph node count and improved survival. In this population-based study of patients undergoing colon cancer surgery, higher lymph node counts did not correlate with increased rates of node-positive status.

References

Jun 1, 1992·Journal of Clinical Epidemiology·R A DeyoM A Ciol
Jan 13, 2000·The New England Journal of Medicine·R GryfeS Gallinger
Jul 11, 2000·Archives of Pathology & Laboratory Medicine·C C ComptonC Willett
Apr 20, 2001·Journal of the National Cancer Institute·H NelsonUNKNOWN National Cancer Institute Expert Panel
Oct 24, 2002·Diseases of the Colon and Rectum·Jan H WongDavid Shimizu
Dec 31, 2002·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Paul M JohnsonGeoff A Porter
Jan 7, 2003·Annals of Surgical Oncology·Richard S SwansonKirby I Bland
Jul 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T E Le VoyerD G Haller
Oct 7, 2003·Annals of Surgical Oncology·F C WrightA J Smith
Nov 5, 2003·Journal of Surgical Oncology·Calvin H L LawAndrew J Smith

❮ Previous
Next ❯

Citations

Oct 25, 2011·Archives of Gynecology and Obstetrics·Joseph T SantosoJim Y Wan
May 25, 2007·Surgical Endoscopy·Michelle A OstadiDavid R Urbach
Sep 20, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·S Yousuf ZafarAmy P Abernethy
Dec 22, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hari NathanTimothy M Pawlik
Jul 3, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M A G ElferinkV E P P Lemmens
Mar 22, 2007·Journal of the National Cancer Institute·George J ChangVirginia A Moyer
Mar 22, 2007·Journal of the National Cancer Institute·Rocco Ricciardi, Nancy N Baxter
Jun 11, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S McPartlandT Osler
Oct 26, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·L FanH L Wang
May 10, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Niamh M Hogan, Desmond C Winter
Dec 6, 2012·Gastroenterology Research and Practice·Masoumeh FaghaniAzadeh Javadi
Oct 15, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shuji OginoCharles S Fuchs
May 31, 2011·Journal of Hematology & Oncology·Chandrakumar ShanmugamUpender Manne
Aug 15, 2013·Journal of Oncology Practice·Helen M ParsonsBeth A Virnig
Oct 14, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sebastian G de la FuenteChristopher R Mantyh
Jul 16, 2014·International Journal of Colorectal Disease·Hung-Hsin LinShih-Ching Chang
Oct 14, 2009·World Journal of Surgery·Kjetil SøreideHartwig Kørner
Dec 18, 2012·World Journal of Surgery·Niamh M Hogan, Desmond C Winter
Mar 26, 2014·Journal of the American College of Surgeons·Cristina N BuddeDaniel O Herzig
Dec 29, 2009·The Journal of Surgical Research·Anna Mary LeungHuan Nguyen Vu
Jul 7, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L N van SteenbergenJ W W Coebergh
May 17, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·D Rohan JeyarajahA Joe Saad
Feb 21, 2009·Journal of the American College of Surgeons·Vassiliki L TsikitisRobert R Cima
Jul 25, 2008·Clinical Colorectal Cancer·Anand Govindarajan, Nancy N Baxter
Nov 17, 2007·American Journal of Surgery·Paul SchumacherThomas Anthony
Sep 19, 2014·International Journal of Cancer. Journal International Du Cancer·Hendrik BläkerMichael Hoffmeister
Nov 26, 2008·Journal of Surgical Oncology·Nancy N Baxter
Feb 24, 2009·Journal of Surgical Oncology·Frances C WrightAndrew J Smith
Oct 16, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J LykkeUNKNOWN Danish Colorectal Cancer Group
Jun 26, 2010·Journal of Surgical Oncology·A RajputD Schrag
Dec 22, 2009·Journal of Surgical Oncology·Andrew J SmithUNKNOWN Expert Panel on Colon and Rectal Cancer Surgery and Pathology
Mar 25, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S KilleenD C Winter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the National Cancer Institute
Nancy N BaxterBeth A Virnig
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
T E Le VoyerDaniel G Haller
JAMA : the Journal of the American Medical Association
Sandra L WongJohn D Birkmeyer
© 2022 Meta ULC. All rights reserved