Lymph node cytopathology: Essential ancillary studies as applied to lymphoproliferative neoplasms

Cancer Cytopathology
Ming Jin, P E Wakely

Abstract

Ancillary testing is absolutely integral to the correct recognition and classification of lymphoid neoplasms as procured with the fine-needle aspiration (FNA) biopsy technique. In patients with a newly diagnosed lymphoid neoplasm, immunophenotyping with flow cytometry, immunohistochemistry, or both is a standard that is currently expected by oncologists before any form of therapy is initiated. This is often the case also for patients with recurrent/relapsed disease. The cellular material obtained with FNA is perfectly suited to meet this demand. That said, the exceptional complexity of modern-day lymphoma classification often precludes definitive subclassification in a subset of lymphomas for a variety of reasons with the FNA biopsy technique, even with the application of ancillary tests. These include a requirement for definitive knowledge of the nodal architecture (eg, Hodgkin lymphoma), of the histologic grade via the counting of cells per microscopic field (follicular lymphoma), and of molecular findings (often unobtainable because of limitations of cellularity). The application of molecular tests to lymph node aspirates continues to evolve but is still largely confined to specialized medical centers. The intent of this art...Continue Reading

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Jan 1, 2017·Journal of the American Society of Cytopathology : JASC·Ming Jin, Paul E Wakely
Jan 1, 2015·Journal of the American Society of Cytopathology : JASC·Paul E Wakely

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Citations

Nov 13, 2018·Diagnostic Cytopathology·Kyriaki SavvidouPanagiota Mikou
Apr 21, 2019·Cytopathology : Official Journal of the British Society for Clinical Cytology·Immacolata CozzolinoPio Zeppa
Aug 1, 2019·American Journal of Clinical Pathology·Kimberly F IngersollEndi Wang
Apr 5, 2021·Journal of the American Society of Cytopathology : JASC·Ahmed ShahMonalisa Sur
Jan 2, 2021·Journal of the American Society of Cytopathology : JASC·Diane Davis Davey
Jun 6, 2021·Journal of the American Society of Cytopathology : JASC·Susan ShyuSyed Z Ali
Sep 12, 2021·American Journal of Clinical Pathology·Sara L ZadehDita Gratzinger
Jan 7, 2022·Der Pathologe·Beata Bode-Lesniewska
Dec 28, 2021·Cytopathology : Official Journal of the British Society for Clinical Cytology·Sana Ahuja, Avneesh Malviya

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