Mar 1, 1976

"Lymph node" form of graft-versus-host reaction in mice

Biulleten' eksperimental'noĭ biologii i meditsiny
D N Maianskiĭ, A N Meĭlikhova


Local type of the graft-versus-host reaction was induced in adult hybrid mice (CBA X C57BL) F1 by the transfer of splenic, thymus and bone marrow CBA cells subcutaneously into the right hind footpad. The weight gain of the regional knee lymph node and blast accumulation in it 7 days later were used as indices of the graft-versus-host activity. After the transfer of 5 and 20 x 10(6) splenic cells the absolute weight of the regional lymph node was 8-10 times higher than that of the contralateral control; it was also significantly greater in comparison with controls which received live syngeneic or semiallogeneic dead cells from the same source. Contrary to controls, in case of the live cells a direct dose-effect dependency could be seen. The lymph node weight gain was accompanied by a regular immunoblast accumulation. The effect of the thymus and the bone marrow cells was less pronounced than that of the splenic cells.

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Mentioned in this Paper

Mice, Inbred CBA
Neoplasm of Uncertain or Unknown Behavior of Thymus
Bone Marrow
Disease of Thymus Gland
Graft Vs Host Reaction
Thymic Tissue
Lymphocyte Activation
Lymph Node Tissue
Lymph Nodes

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