PMID: 9422315Jan 9, 1998Paper

Lymph node histology in typical and atypical chronic lymphocytic leukemia

The American Journal of Surgical Pathology
M BonatoC De Wolf-Peeters

Abstract

According to the French-American-British (FAB) proposal on the classification of chronic lymphoid leukemia (CLL), the disorder can be subdivided into typical and atypical CLL. We recently demonstrated the prognostic significance of this subgrouping and based on these results we suggested that typical and atypical CLL represent two closely related, but different entities. These results prompted us to investigate 42 patients diagnosed with CLL based on the results of lymph node biopsy in order to identify the histologic counterpart of the CLL variants. A first group of 14 cases showed a monomorphic proliferation of small round lymphocytes associated with the occurrence of small pseudofollicles. All these cases were diagnosed as typical CLL on peripheral blood (13 cases) or bone marrow smear (1 case). The remaining 28 cases showed aberrant histologic features characterized by the presence of large numbers of paraimmunoblasts and prolymphocytes, forming very large pseudofollicles, and/or by nuclear irregularities of the neoplastic cells. Based on peripheral blood smears (22 cases) or bone marrow smears (six cases), two cases showed no peripheral blood involvement, 21 cases were diagnosed as atypical CLL, and five as typical CLL. Fr...Continue Reading

References

Jan 1, 1979·British Journal of Haematology·A EnnoD A Galton
Jan 1, 1978·Cancer·F R Dick, R D Maca
Apr 1, 1990·Cancer Genetics and Cytogenetics·G Juliusson, G Gahrton
Jan 1, 1989·Leukemia Research·P Reizenstein
Sep 1, 1989·Journal of Clinical Pathology·M S De OliveiraD Catovsky
Dec 1, 1981·Cancer·C R Kjeldsberg, J Marty
Jul 1, 1994·British Journal of Haematology·A CrielH Van den Berghe
Apr 1, 1996·American Journal of Clinical Pathology·W G FinnL C Peterson
Jan 1, 1996·Genes, Chromosomes & Cancer·L MichauxH Van Den Berghe

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Citations

Apr 25, 2001·Histopathology·H K Müller-HermelinkG Ott
Jan 22, 2002·The American Journal of Dermatopathology·B R MoodyM D Kraus
Apr 30, 2002·The American Journal of Surgical Pathology·Sheryl L AsplundSteven H Kroft
May 7, 2011·Haematologica·Sarah E GibsonRobert P Hasserjian
Apr 8, 1999·Leukemia & Lymphoma·A CrielC De Wolf-Peeters
Feb 28, 2002·American Journal of Clinical Pathology·Kit-fai WongJohn K C Chan
Jan 24, 2006·Human Pathology·Lorinda A SomaSteven H Swerdlow
Apr 6, 2002·Clinics in Laboratory Medicine·Antonio M Hernandez
Aug 25, 2004·Hematology/oncology Clinics of North America·Stefano A PileriTeresa Marafioti
Jul 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Federico Caligaris-Cappio, Paolo Ghia
Sep 22, 2018·Critical Reviews in Clinical Laboratory Sciences·Ancuta JurjIoana Berindan-Neagoe
Sep 4, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yen-Chun LiuJulia T Geyer
Apr 2, 2020·Cold Spring Harbor Perspectives in Medicine·Nicholas ChiorazziKanti R Rai
Aug 27, 2019·La Presse médicale·Christophe BontouxThierry Jo Molina

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