Lymph node involvement by enteropathy-like indolent NK-cell proliferation.

Virchows Archiv : an International Journal of Pathology
Jean-Louis DargentLaurence de Leval

Abstract

Natural killer (NK)-cell enteropathy (NKCE) and lymphomatoid gastropathy (LG) are closely related lymphoproliferative disorders (LPDs) composed of mature and Epstein-Barr virus (EBV)-negative NK-cells. Although these uncommon and indolent lymphoid proliferations mostly arise within the gastrointestinal (GI) tract as their designations implies, a few cases have been reported outside the GI tract. We hereby describe a unique case of lymph node infiltration by such EBV-negative NK-cell proliferation fortuitously found during routine examination of a gallbladder resected for biliary lithiasis. The histologic, phenotypic, and molecular features of this NK-cell proliferation, which were very similar if not identical to those previously reported in NKCE or LG, suggest that similar indolent EBV-negative NK-cell LPDs may also occasionally involve lymph nodes.

References

Apr 21, 2006·The American Journal of Surgical Pathology·Francisco VegaElaine S Jaffe
May 9, 2012·World Journal of Gastroenterology : WJG·Tomohiro TeraiKen Sugimoto
May 2, 2015·The American Journal of Surgical Pathology·Katsuyoshi TakataTadashi Yoshino
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Oct 15, 2019·The American Journal of Surgical Pathology·Rahul KrishnanAlejandro A Gru

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