Lymph node metastases in thymic malignancies: a Chinese Alliance for Research in Thymomas retrospective database analysis

Interactive Cardiovascular and Thoracic Surgery
Zhitao GuMembers of the Chinese Alliance for Research in Thymomas

Abstract

Lymphatic involvement is believed to be relatively rare in thymic epithelial tumours. The incidence and prognostic significance of nodal metastases are still unclear. The goal of this study was to define the incidence and prognostic relevance of nodal metastasis in patients with thymic epithelial tumours, using a nationwide retrospective database of the Chinese Alliance for Research in Thymomas. Patients who underwent upfront surgical resection without preoperative therapy were enrolled for the study. The International Thymic Malignancies Interest Group proposal of a new staging system for thymic epithelial tumours was used to redefine the pathological stage. The incidence of nodal metastasis and its relationship with clinicopathological characteristics and its impact on survival were examined accordingly. A total of 1617 patients were enrolled in this study. Lymph node metastasis was identified in 35 patients (2.2%). No nodal involvement was found in type A, AB or B1 thymomas. The incidence of nodal metastasis in thymoma (B2/B3) and thymic carcinoma was 1.3% and 7.9%, respectively, and it was most commonly seen in patients with neuroendocrine thymic tumours (16.7%, P < 0.001). According to the primary tumour invasion stage, in...Continue Reading

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Citations

Dec 29, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Wentao FangEnrico Ruffini
Nov 13, 2020·Seminars in Thoracic and Cardiovascular Surgery·Zi-Ming WangMahmoud Ismail
Jun 1, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hugo ClermidyFrançois Tronc
Jun 22, 2021·Interactive Cardiovascular and Thoracic Surgery·Masatsugu HamajiHiroshi Date

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