Lymph node metastasis in thymic malignancies: A Chinese multicenter prospective observational study

The Journal of Thoracic and Cardiovascular Surgery
Wentao FangMembers of the Chinese Alliance for Research in Thymomas

Abstract

To study the incidence and pattern of lymph node metastases in thymic malignancies. This multicenter prospective observational trial with intentional lymph node dissection was carried out by the Chinese Alliance for Research in Thymomas (ChART). Data on patients with thymic tumors without pretreatment were collected prospectively. Results from this prospective study were then compared with those from a previously reported ChART retrospective study. Among 275 patients, metastasis was detected in 41 nodes (3.04%) in 15 patients (5.5%). The rate of lymph node metastasis was 2.1% (5/238) in patients with thymomas, 25% (6/24) in those with thymic carcinomas, and 50% (4/8) in those with neuroendocrine tumors (P < .001). The rate of lymph node metastasis in category T1 to T4 tumors was 2.7% (6/222) in T1, 7.7% (1/13) in T2, 18.4% (7/38) in T3, and 50% (1/2) in T4 (P < .001). Nodal involvement was significantly higher compared with the ChART retrospective study (5.5% vs 2.2%; P = .002), although the 2 groups were comparable in terms of tumor stage and histology. Metastasis was found in N1 nodes in 13 patients (86.7%) and in N2 nodes in 8 patients (53.3%); 6 patients (40%) had simultaneous N1/N2 diseases and 6 (40%) had multistation inv...Continue Reading

Citations

Sep 18, 2020·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Charles T BakhosAbbas E Abbas
Dec 29, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Wentao FangEnrico Ruffini
Nov 30, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Enrico RuffiniUNKNOWN Members of the Advisory Boards
Feb 19, 2021·Seminars in Thoracic and Cardiovascular Surgery·Sean Jordan, Sai Yendamuri
Nov 13, 2020·Seminars in Thoracic and Cardiovascular Surgery·Zi-Ming WangMahmoud Ismail
Jun 1, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hugo ClermidyFrançois Tronc
Jun 22, 2021·Interactive Cardiovascular and Thoracic Surgery·Masatsugu HamajiHiroshi Date

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